A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation
Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/18/11/3905 |
| _version_ | 1828109282147565568 |
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| author | Emanuela Marcelli Barbara Bortolani Ivan Corazza Laura Cercenelli |
| author_facet | Emanuela Marcelli Barbara Bortolani Ivan Corazza Laura Cercenelli |
| author_sort | Emanuela Marcelli |
| collection | DOAJ |
| description | Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the leaflets motion using an electric impedance measurement, IntraValvular Impedance (IVI). Methods: For IVI measurement, dedicated electrodes are embedded in the structure of the HVP to generate a local electric field that is altered by the moving valve leaflets during their cyclic opening/closing. We present preliminary in vitro results using a first prototype of sensorized mechanical heart valve connected to an external impedance measurement system. The prototype was tested on a circulatory mock loop system and the IVI signals were recorded during both normal dynamics and experimentally induced altered working of the leaflets. Results: Recordings showed a very repetitive and stable IVI signal during the normal cyclic opening/closing of the HVP. The induced alterations in leaflet motion were reflected in the IVI signal. Conclusions: The novel sensorized HVP has great potential to give early warning of possible subclinical valve thrombosis altering the valve leaflet motion, and to help in tailoring the anticoagulation therapy. |
| first_indexed | 2024-04-11T11:00:05Z |
| format | Article |
| id | doaj.art-d08ed781941a4a138e81dcace84fef22 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T11:00:05Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-d08ed781941a4a138e81dcace84fef222022-12-22T04:28:38ZengMDPI AGSensors1424-82202018-11-011811390510.3390/s18113905s18113905A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro EvaluationEmanuela Marcelli0Barbara Bortolani1Ivan Corazza2Laura Cercenelli3Laboratory of Bioengineering, DIMES Department, University of Bologna, S. Orsola-Malpighi Hospital, 40138 Bologna, ItalyLaboratory of Bioengineering, DIMES Department, University of Bologna, S. Orsola-Malpighi Hospital, 40138 Bologna, ItalyMedical Physics Activities Coordination Center, DIMES Department, University of Bologna, 40138 Bologna, ItalyLaboratory of Bioengineering, DIMES Department, University of Bologna, S. Orsola-Malpighi Hospital, 40138 Bologna, ItalyBackground: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the leaflets motion using an electric impedance measurement, IntraValvular Impedance (IVI). Methods: For IVI measurement, dedicated electrodes are embedded in the structure of the HVP to generate a local electric field that is altered by the moving valve leaflets during their cyclic opening/closing. We present preliminary in vitro results using a first prototype of sensorized mechanical heart valve connected to an external impedance measurement system. The prototype was tested on a circulatory mock loop system and the IVI signals were recorded during both normal dynamics and experimentally induced altered working of the leaflets. Results: Recordings showed a very repetitive and stable IVI signal during the normal cyclic opening/closing of the HVP. The induced alterations in leaflet motion were reflected in the IVI signal. Conclusions: The novel sensorized HVP has great potential to give early warning of possible subclinical valve thrombosis altering the valve leaflet motion, and to help in tailoring the anticoagulation therapy.https://www.mdpi.com/1424-8220/18/11/3905heart valve prosthesisvalve thrombosiselectric impedanceimplantable sensorcontinuous monitoring |
| spellingShingle | Emanuela Marcelli Barbara Bortolani Ivan Corazza Laura Cercenelli A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation Sensors heart valve prosthesis valve thrombosis electric impedance implantable sensor continuous monitoring |
| title | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
| title_full | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
| title_fullStr | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
| title_full_unstemmed | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
| title_short | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
| title_sort | novel sensorized heart valve prosthesis preliminary in vitro evaluation |
| topic | heart valve prosthesis valve thrombosis electric impedance implantable sensor continuous monitoring |
| url | https://www.mdpi.com/1424-8220/18/11/3905 |
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