The spatial and temporal structure of neural activity across the fly brain
Abstract What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spont...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41261-2 |
| _version_ | 1797558546823380992 |
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| author | Evan S. Schaffer Neeli Mishra Matthew R. Whiteway Wenze Li Michelle B. Vancura Jason Freedman Kripa B. Patel Venkatakaushik Voleti Liam Paninski Elizabeth M. C. Hillman L. F. Abbott Richard Axel |
| author_facet | Evan S. Schaffer Neeli Mishra Matthew R. Whiteway Wenze Li Michelle B. Vancura Jason Freedman Kripa B. Patel Venkatakaushik Voleti Liam Paninski Elizabeth M. C. Hillman L. F. Abbott Richard Axel |
| author_sort | Evan S. Schaffer |
| collection | DOAJ |
| description | Abstract What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity of small clusters of spatially organized neurons that may correspond to genetically defined cell types. These clusters participate in the global dynamics, indicating that neural activity reflects a combination of local and broadly distributed components. This suggests that microcircuits with highly specified functions are provided with knowledge of the larger context in which they operate. |
| first_indexed | 2024-03-10T17:32:59Z |
| format | Article |
| id | doaj.art-d08f5553e8c34844b675449dc96651d0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:32:59Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d08f5553e8c34844b675449dc96651d02023-11-20T09:58:19ZengNature PortfolioNature Communications2041-17232023-09-0114111510.1038/s41467-023-41261-2The spatial and temporal structure of neural activity across the fly brainEvan S. Schaffer0Neeli Mishra1Matthew R. Whiteway2Wenze Li3Michelle B. Vancura4Jason Freedman5Kripa B. Patel6Venkatakaushik Voleti7Liam Paninski8Elizabeth M. C. Hillman9L. F. Abbott10Richard Axel11Mortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityMortimer B. Zuckerman Mind Brain Behavior Institute and Department of Neuroscience, Columbia UniversityAbstract What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity of small clusters of spatially organized neurons that may correspond to genetically defined cell types. These clusters participate in the global dynamics, indicating that neural activity reflects a combination of local and broadly distributed components. This suggests that microcircuits with highly specified functions are provided with knowledge of the larger context in which they operate.https://doi.org/10.1038/s41467-023-41261-2 |
| spellingShingle | Evan S. Schaffer Neeli Mishra Matthew R. Whiteway Wenze Li Michelle B. Vancura Jason Freedman Kripa B. Patel Venkatakaushik Voleti Liam Paninski Elizabeth M. C. Hillman L. F. Abbott Richard Axel The spatial and temporal structure of neural activity across the fly brain Nature Communications |
| title | The spatial and temporal structure of neural activity across the fly brain |
| title_full | The spatial and temporal structure of neural activity across the fly brain |
| title_fullStr | The spatial and temporal structure of neural activity across the fly brain |
| title_full_unstemmed | The spatial and temporal structure of neural activity across the fly brain |
| title_short | The spatial and temporal structure of neural activity across the fly brain |
| title_sort | spatial and temporal structure of neural activity across the fly brain |
| url | https://doi.org/10.1038/s41467-023-41261-2 |
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