Effects of hallucinogenic drugs on the human heart
Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT2A-serotonin receptors in the brain. However, a close study reveals that they also act on the heart, possibly increas...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1334218/full |
| _version_ | 1827365269775843328 |
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| author | Joachim Neumann Stefan Dhein Uwe Kirchhefer Britt Hofmann Ulrich Gergs |
| author_facet | Joachim Neumann Stefan Dhein Uwe Kirchhefer Britt Hofmann Ulrich Gergs |
| author_sort | Joachim Neumann |
| collection | DOAJ |
| description | Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT2A-serotonin receptors in the brain. However, a close study reveals that they also act on the heart, possibly increasing the force of contraction and beating rate and may lead to arrhythmias. Here, we will review the inotropic and chronotropic actions of bufotenin, psilocin, psilocybin, lysergic acid diethylamide (LSD), ergotamine, ergometrine, N,N-dimethyltryptamine, and 5-methoxy-N,N-dimethyltryptamine in the human heart. |
| first_indexed | 2024-03-08T08:25:51Z |
| format | Article |
| id | doaj.art-d08f83af76b94f0599aada5f6b5435bd |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T08:25:51Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-d08f83af76b94f0599aada5f6b5435bd2024-02-02T04:50:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.13342181334218Effects of hallucinogenic drugs on the human heartJoachim Neumann0Stefan Dhein1Uwe Kirchhefer2Britt Hofmann3Ulrich Gergs4Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, GermanyRudolf-Boehm Institut für Pharmakologie und Toxikologie, Universität Leipzig, Leipzig, GermanyInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Universität Münster, Münster, GermanyInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, GermanyInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, GermanyHallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT2A-serotonin receptors in the brain. However, a close study reveals that they also act on the heart, possibly increasing the force of contraction and beating rate and may lead to arrhythmias. Here, we will review the inotropic and chronotropic actions of bufotenin, psilocin, psilocybin, lysergic acid diethylamide (LSD), ergotamine, ergometrine, N,N-dimethyltryptamine, and 5-methoxy-N,N-dimethyltryptamine in the human heart.https://www.frontiersin.org/articles/10.3389/fphar.2024.1334218/fullbufoteninpsilocinpsilocybinLSDergotamineergometrine |
| spellingShingle | Joachim Neumann Stefan Dhein Uwe Kirchhefer Britt Hofmann Ulrich Gergs Effects of hallucinogenic drugs on the human heart Frontiers in Pharmacology bufotenin psilocin psilocybin LSD ergotamine ergometrine |
| title | Effects of hallucinogenic drugs on the human heart |
| title_full | Effects of hallucinogenic drugs on the human heart |
| title_fullStr | Effects of hallucinogenic drugs on the human heart |
| title_full_unstemmed | Effects of hallucinogenic drugs on the human heart |
| title_short | Effects of hallucinogenic drugs on the human heart |
| title_sort | effects of hallucinogenic drugs on the human heart |
| topic | bufotenin psilocin psilocybin LSD ergotamine ergometrine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1334218/full |
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