Size Control of Biomimetic Curved-Edge Vaterite with Chiral Toroid Morphology via Sonochemical Synthesis
The metastable vaterite polymorph of calcium carbonate (CaCO<sub>3</sub>) holds significant practical importance, particularly in regenerative medicine, drug delivery, and various personal care products. Controlling the size and morphology of vaterite particles is crucial for biomedical...
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MDPI AG
2024-03-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/9/3/174 |
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| author | Ki Ha Min Dong Hyun Kim Seung Pil Pack |
| author_facet | Ki Ha Min Dong Hyun Kim Seung Pil Pack |
| author_sort | Ki Ha Min |
| collection | DOAJ |
| description | The metastable vaterite polymorph of calcium carbonate (CaCO<sub>3</sub>) holds significant practical importance, particularly in regenerative medicine, drug delivery, and various personal care products. Controlling the size and morphology of vaterite particles is crucial for biomedical applications. This study explored the synergistic effect of ultrasonic (US) irradiation and acidic amino acids on CaCO<sub>3</sub> synthesis, specifically the size, dispersity, and crystallographic phase of curved-edge vaterite with chiral toroids (chiral-curved vaterite). We employed 40 kHz US irradiation and introduced L- or D-aspartic acid as an additive for the formation of spheroidal chiral-curved vaterite in an aqueous solution of CaCl<sub>2</sub> and Na<sub>2</sub>CO<sub>3</sub> at 20 ± 1 °C. Chiral-curved vaterites precipitated through mechanical stirring (without US irradiation) exhibited a particle size of approximately 15 μm, whereas those formed under US irradiation were approximately 6 μm in size and retained their chiral topoid morphology. When a fluorescent dye was used for the analysis of loading efficiency, the size-reduced vaterites with chiral morphology, produced through US irradiation, exhibited a larger loading efficiency than the vaterites produced without US irradiation. These results hold significant value for the preparation of biomimetic chiral-curved CaCO<sub>3</sub>, specifically size-reduced vaterites, as versatile biomaterials for material filling, drug delivery, and bone regeneration. |
| first_indexed | 2024-04-24T18:30:36Z |
| format | Article |
| id | doaj.art-d08fd42598004c7e956cf573eefd390e |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-04-24T18:30:36Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
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| series | Biomimetics |
| spelling | doaj.art-d08fd42598004c7e956cf573eefd390e2024-03-27T13:27:42ZengMDPI AGBiomimetics2313-76732024-03-019317410.3390/biomimetics9030174Size Control of Biomimetic Curved-Edge Vaterite with Chiral Toroid Morphology via Sonochemical SynthesisKi Ha Min0Dong Hyun Kim1Seung Pil Pack2Institute of Industrial Technology, Korea University, Sejong 30019, Republic of KoreaDepartment of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of KoreaDepartment of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of KoreaThe metastable vaterite polymorph of calcium carbonate (CaCO<sub>3</sub>) holds significant practical importance, particularly in regenerative medicine, drug delivery, and various personal care products. Controlling the size and morphology of vaterite particles is crucial for biomedical applications. This study explored the synergistic effect of ultrasonic (US) irradiation and acidic amino acids on CaCO<sub>3</sub> synthesis, specifically the size, dispersity, and crystallographic phase of curved-edge vaterite with chiral toroids (chiral-curved vaterite). We employed 40 kHz US irradiation and introduced L- or D-aspartic acid as an additive for the formation of spheroidal chiral-curved vaterite in an aqueous solution of CaCl<sub>2</sub> and Na<sub>2</sub>CO<sub>3</sub> at 20 ± 1 °C. Chiral-curved vaterites precipitated through mechanical stirring (without US irradiation) exhibited a particle size of approximately 15 μm, whereas those formed under US irradiation were approximately 6 μm in size and retained their chiral topoid morphology. When a fluorescent dye was used for the analysis of loading efficiency, the size-reduced vaterites with chiral morphology, produced through US irradiation, exhibited a larger loading efficiency than the vaterites produced without US irradiation. These results hold significant value for the preparation of biomimetic chiral-curved CaCO<sub>3</sub>, specifically size-reduced vaterites, as versatile biomaterials for material filling, drug delivery, and bone regeneration.https://www.mdpi.com/2313-7673/9/3/174calcium carbonatevateritechiral toroidaspartic acidsonochemical synthesis |
| spellingShingle | Ki Ha Min Dong Hyun Kim Seung Pil Pack Size Control of Biomimetic Curved-Edge Vaterite with Chiral Toroid Morphology via Sonochemical Synthesis Biomimetics calcium carbonate vaterite chiral toroid aspartic acid sonochemical synthesis |
| title | Size Control of Biomimetic Curved-Edge Vaterite with Chiral Toroid Morphology via Sonochemical Synthesis |
| title_full | Size Control of Biomimetic Curved-Edge Vaterite with Chiral Toroid Morphology via Sonochemical Synthesis |
| title_fullStr | Size Control of Biomimetic Curved-Edge Vaterite with Chiral Toroid Morphology via Sonochemical Synthesis |
| title_full_unstemmed | Size Control of Biomimetic Curved-Edge Vaterite with Chiral Toroid Morphology via Sonochemical Synthesis |
| title_short | Size Control of Biomimetic Curved-Edge Vaterite with Chiral Toroid Morphology via Sonochemical Synthesis |
| title_sort | size control of biomimetic curved edge vaterite with chiral toroid morphology via sonochemical synthesis |
| topic | calcium carbonate vaterite chiral toroid aspartic acid sonochemical synthesis |
| url | https://www.mdpi.com/2313-7673/9/3/174 |
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