Phage Therapy in Gastrointestinal Diseases
Gastrointestinal tract microbiota plays a key role in the regulation of the pathogenesis of several gastrointestinal diseases. In particular, the viral fraction, composed essentially of bacteriophages, influences homeostasis by exerting a selective pressure on the bacterial communities living in the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/9/1420 |
| _version_ | 1797553611212849152 |
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| author | Beatriz Gutiérrez Pilar Domingo-Calap |
| author_facet | Beatriz Gutiérrez Pilar Domingo-Calap |
| author_sort | Beatriz Gutiérrez |
| collection | DOAJ |
| description | Gastrointestinal tract microbiota plays a key role in the regulation of the pathogenesis of several gastrointestinal diseases. In particular, the viral fraction, composed essentially of bacteriophages, influences homeostasis by exerting a selective pressure on the bacterial communities living in the tract. Gastrointestinal inflammatory diseases are mainly induced by bacteria, and have risen due to the emergence of antibiotic resistant strains. In the lack of effective treatments, phage therapy has been proposed as a clinical alternative to restore intestinal eubiosis, thanks to its immunomodulatory and bactericidal effect against bacterial pathogens, such as <i>Clostridioides difficile</i> in ulcerative colitis and invasive adherent <i>Escherichia coli</i> in Crohn’s disease. In addition, genetically modified temperate phages could be used to suppress the transcription of bacterial virulence factors. In this review, we will highlight the latest advances in research in the field, as well as the clinical trials based on phage therapy in the area of gastroenterology. |
| first_indexed | 2024-03-10T16:18:59Z |
| format | Article |
| id | doaj.art-d092c7be035a46dfb66cfaa9460a8cc3 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T16:18:59Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-d092c7be035a46dfb66cfaa9460a8cc32023-11-20T13:52:45ZengMDPI AGMicroorganisms2076-26072020-09-0189142010.3390/microorganisms8091420Phage Therapy in Gastrointestinal DiseasesBeatriz Gutiérrez0Pilar Domingo-Calap1Department of Genetics, Universitat de València, 46100 Valencia, SpainDepartment of Genetics, Universitat de València, 46100 Valencia, SpainGastrointestinal tract microbiota plays a key role in the regulation of the pathogenesis of several gastrointestinal diseases. In particular, the viral fraction, composed essentially of bacteriophages, influences homeostasis by exerting a selective pressure on the bacterial communities living in the tract. Gastrointestinal inflammatory diseases are mainly induced by bacteria, and have risen due to the emergence of antibiotic resistant strains. In the lack of effective treatments, phage therapy has been proposed as a clinical alternative to restore intestinal eubiosis, thanks to its immunomodulatory and bactericidal effect against bacterial pathogens, such as <i>Clostridioides difficile</i> in ulcerative colitis and invasive adherent <i>Escherichia coli</i> in Crohn’s disease. In addition, genetically modified temperate phages could be used to suppress the transcription of bacterial virulence factors. In this review, we will highlight the latest advances in research in the field, as well as the clinical trials based on phage therapy in the area of gastroenterology.https://www.mdpi.com/2076-2607/8/9/1420bacteriophagemicrobiomeviromedysbiosisphage therapygastrointestinal tract |
| spellingShingle | Beatriz Gutiérrez Pilar Domingo-Calap Phage Therapy in Gastrointestinal Diseases Microorganisms bacteriophage microbiome virome dysbiosis phage therapy gastrointestinal tract |
| title | Phage Therapy in Gastrointestinal Diseases |
| title_full | Phage Therapy in Gastrointestinal Diseases |
| title_fullStr | Phage Therapy in Gastrointestinal Diseases |
| title_full_unstemmed | Phage Therapy in Gastrointestinal Diseases |
| title_short | Phage Therapy in Gastrointestinal Diseases |
| title_sort | phage therapy in gastrointestinal diseases |
| topic | bacteriophage microbiome virome dysbiosis phage therapy gastrointestinal tract |
| url | https://www.mdpi.com/2076-2607/8/9/1420 |
| work_keys_str_mv | AT beatrizgutierrez phagetherapyingastrointestinaldiseases AT pilardomingocalap phagetherapyingastrointestinaldiseases |