Lignocellulosic Membranes Grafted with <i>N</i>-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin
Radiation chemistry presents a unique avenue for developing innovative polymeric materials with desirable properties, eliminating the need for chemical initiators, which can be potentially detrimental, especially in sensitive sectors like medicine. In this investigation, we employed a radiation-indu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/16/4/551 |
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| author | Maite Rentería-Urquiza Guadalupe Gabriel Flores-Rojas Belén Gómez-Lázaro Felipe López-Saucedo Ricardo Vera-Graziano Eduardo Mendizabal Emilio Bucio |
| author_facet | Maite Rentería-Urquiza Guadalupe Gabriel Flores-Rojas Belén Gómez-Lázaro Felipe López-Saucedo Ricardo Vera-Graziano Eduardo Mendizabal Emilio Bucio |
| author_sort | Maite Rentería-Urquiza |
| collection | DOAJ |
| description | Radiation chemistry presents a unique avenue for developing innovative polymeric materials with desirable properties, eliminating the need for chemical initiators, which can be potentially detrimental, especially in sensitive sectors like medicine. In this investigation, we employed a radiation-induced graft polymerization process with N-vinylcaprolactam (NVCL) to modify lignocellulosic membranes derived from <i>Agave salmiana</i>, commonly known as maguey. The membranes underwent thorough characterization employing diverse techniques, including contact angle measurement, degree of swelling, scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier-transform infrared-attenuated total reflectance spectroscopy (FTIR-ATR), nuclear magnetic resonance (CP-MAS <sup>13</sup>C-NMR), X-ray photoelectron spectroscopy (XPS), and uniaxial tensile mechanical tests. The membranes’ ability to load and release an antimicrobial glycopeptide drug was assessed, revealing significant enhancements in both drug loading and sustained release. The grafting of PNVCL contributed to prolonged sustained release by decreasing the drug release rate at temperatures above the LCST. The release profiles were analyzed using the Higuchi, Peppas–Sahlin, and Korsmeyer–Peppas models, suggesting a Fickian transport mechanism as indicated by the Korsmeyer–Peppas model. |
| first_indexed | 2024-03-07T22:16:20Z |
| format | Article |
| id | doaj.art-d093077c1f884e71ad38930e99b67655 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-07T22:16:20Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-d093077c1f884e71ad38930e99b676552024-02-23T15:32:24ZengMDPI AGPolymers2073-43602024-02-0116455110.3390/polym16040551Lignocellulosic Membranes Grafted with <i>N</i>-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of VancomycinMaite Rentería-Urquiza0Guadalupe Gabriel Flores-Rojas1Belén Gómez-Lázaro2Felipe López-Saucedo3Ricardo Vera-Graziano4Eduardo Mendizabal5Emilio Bucio6Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. M. García Barragán #1451, Guadalajara 44430, MexicoDepartamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. M. García Barragán #1451, Guadalajara 44430, MexicoDepartamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City 04510, MexicoDepartamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City 04510, MexicoInstituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoDepartamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. M. García Barragán #1451, Guadalajara 44430, MexicoDepartamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City 04510, MexicoRadiation chemistry presents a unique avenue for developing innovative polymeric materials with desirable properties, eliminating the need for chemical initiators, which can be potentially detrimental, especially in sensitive sectors like medicine. In this investigation, we employed a radiation-induced graft polymerization process with N-vinylcaprolactam (NVCL) to modify lignocellulosic membranes derived from <i>Agave salmiana</i>, commonly known as maguey. The membranes underwent thorough characterization employing diverse techniques, including contact angle measurement, degree of swelling, scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier-transform infrared-attenuated total reflectance spectroscopy (FTIR-ATR), nuclear magnetic resonance (CP-MAS <sup>13</sup>C-NMR), X-ray photoelectron spectroscopy (XPS), and uniaxial tensile mechanical tests. The membranes’ ability to load and release an antimicrobial glycopeptide drug was assessed, revealing significant enhancements in both drug loading and sustained release. The grafting of PNVCL contributed to prolonged sustained release by decreasing the drug release rate at temperatures above the LCST. The release profiles were analyzed using the Higuchi, Peppas–Sahlin, and Korsmeyer–Peppas models, suggesting a Fickian transport mechanism as indicated by the Korsmeyer–Peppas model.https://www.mdpi.com/2073-4360/16/4/551lignocellulosebio-membraneskin magueybiopolymergraftingthermal responsiveness |
| spellingShingle | Maite Rentería-Urquiza Guadalupe Gabriel Flores-Rojas Belén Gómez-Lázaro Felipe López-Saucedo Ricardo Vera-Graziano Eduardo Mendizabal Emilio Bucio Lignocellulosic Membranes Grafted with <i>N</i>-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin Polymers lignocellulose bio-membrane skin maguey biopolymer grafting thermal responsiveness |
| title | Lignocellulosic Membranes Grafted with <i>N</i>-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin |
| title_full | Lignocellulosic Membranes Grafted with <i>N</i>-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin |
| title_fullStr | Lignocellulosic Membranes Grafted with <i>N</i>-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin |
| title_full_unstemmed | Lignocellulosic Membranes Grafted with <i>N</i>-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin |
| title_short | Lignocellulosic Membranes Grafted with <i>N</i>-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin |
| title_sort | lignocellulosic membranes grafted with i n i vinylcaprolactam using radiation chemistry load and release capacity of vancomycin |
| topic | lignocellulose bio-membrane skin maguey biopolymer grafting thermal responsiveness |
| url | https://www.mdpi.com/2073-4360/16/4/551 |
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