Topical application of 0.05% cyclosporine A as an adjunct to LASIK
Purpose. To study topical 0.05% cyclosporine A as an adjunct to LASIK in patients with a high percentage of altered (corneal) tissue (PAT) and, consequently, with a high susceptibility risk to the post-LASIK dry eye syndrome.Material and methods. This study included 23 patients (48 eyes) with PTA≥0....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Publishing house "Ophthalmology"
2015-12-01
|
| Series: | Офтальмохирургия |
| Subjects: | |
| Online Access: | https://www.ophthalmosurgery.ru/jour/article/view/192 |
| _version_ | 1797946733972422656 |
|---|---|
| author | E. V. Kudryashova D. S. Maltsev |
| author_facet | E. V. Kudryashova D. S. Maltsev |
| author_sort | E. V. Kudryashova |
| collection | DOAJ |
| description | Purpose. To study topical 0.05% cyclosporine A as an adjunct to LASIK in patients with a high percentage of altered (corneal) tissue (PAT) and, consequently, with a high susceptibility risk to the post-LASIK dry eye syndrome.Material and methods. This study included 23 patients (48 eyes) with PTA≥0.4 (40%) ((PTA=(PFT+CAD)/PCT, PFT – predicted flap thickness, CAD – calculated ablation depth, PCT – preoperative corneal thickness). The patients were divided into 2 study groups: (1) standard postoperative treatment and an additional topical 0.05% cyclosporine A (3 months preoperatively and within 1 month postoperatively) and (2) standard postoperative treatment. Instability of surface regularity index (ISRI), tear production and corneal sensitivity were estimated 90±10 days preoperatively and 30±3 days postoperatively.Results. There was no statistically significant difference in ISRI, tear production and corneal sensitivity between the study groups at initial control point of investigation 90±10 days preoperatively. In the follow-up period of 30±3 days postoperatively the dynamics to an ISRI increase, a reduction of tear production and corneal sensitivity compared to preoperative values was detected in both groups. The ISRI was significantly higher in the group 2 compared to the group 1 (0.37±0.06 and 0.28±0.07, respectively, p=0.017), the tear production was significantly lower in the group 2 compared to group 1 (11.4±2.7mm and 13.8±3.6mm, respectively, p=0.021), the corneal sensitivity was significantly lower in the group 2 compared to the group 1 (34.9±5.7mm and 48.2±6.6mm,respectively, p=0.003).Conclusion. The topical application of 0.05% cyclosporine A as an pre- and post-operative adjunct to LASIK in the patients with the high PAT value (≥0.4 (40%)) reduces a severity of symptoms of post-LASIK dry eye syndrome. |
| first_indexed | 2024-04-10T21:15:47Z |
| format | Article |
| id | doaj.art-d096083c833f4821b2fef3dbad65e733 |
| institution | Directory Open Access Journal |
| issn | 0235-4160 2312-4970 |
| language | Russian |
| last_indexed | 2024-04-10T21:15:47Z |
| publishDate | 2015-12-01 |
| publisher | Publishing house "Ophthalmology" |
| record_format | Article |
| series | Офтальмохирургия |
| spelling | doaj.art-d096083c833f4821b2fef3dbad65e7332023-01-20T12:34:49ZrusPublishing house "Ophthalmology"Офтальмохирургия0235-41602312-49702015-12-01036974190Topical application of 0.05% cyclosporine A as an adjunct to LASIKE. V. Kudryashova0D. S. Maltsev1The S.M. Kirov Militar y Medical Academy, the Chair of Ophthalmology , St.-PetersburgThe S.M. Kirov Militar y Medical Academy, the Chair of Ophthalmology , St.-PetersburgPurpose. To study topical 0.05% cyclosporine A as an adjunct to LASIK in patients with a high percentage of altered (corneal) tissue (PAT) and, consequently, with a high susceptibility risk to the post-LASIK dry eye syndrome.Material and methods. This study included 23 patients (48 eyes) with PTA≥0.4 (40%) ((PTA=(PFT+CAD)/PCT, PFT – predicted flap thickness, CAD – calculated ablation depth, PCT – preoperative corneal thickness). The patients were divided into 2 study groups: (1) standard postoperative treatment and an additional topical 0.05% cyclosporine A (3 months preoperatively and within 1 month postoperatively) and (2) standard postoperative treatment. Instability of surface regularity index (ISRI), tear production and corneal sensitivity were estimated 90±10 days preoperatively and 30±3 days postoperatively.Results. There was no statistically significant difference in ISRI, tear production and corneal sensitivity between the study groups at initial control point of investigation 90±10 days preoperatively. In the follow-up period of 30±3 days postoperatively the dynamics to an ISRI increase, a reduction of tear production and corneal sensitivity compared to preoperative values was detected in both groups. The ISRI was significantly higher in the group 2 compared to the group 1 (0.37±0.06 and 0.28±0.07, respectively, p=0.017), the tear production was significantly lower in the group 2 compared to group 1 (11.4±2.7mm and 13.8±3.6mm, respectively, p=0.021), the corneal sensitivity was significantly lower in the group 2 compared to the group 1 (34.9±5.7mm and 48.2±6.6mm,respectively, p=0.003).Conclusion. The topical application of 0.05% cyclosporine A as an pre- and post-operative adjunct to LASIK in the patients with the high PAT value (≥0.4 (40%)) reduces a severity of symptoms of post-LASIK dry eye syndrome.https://www.ophthalmosurgery.ru/jour/article/view/192lasikdry eye syndromecyclosporinecorneal flapablation depth |
| spellingShingle | E. V. Kudryashova D. S. Maltsev Topical application of 0.05% cyclosporine A as an adjunct to LASIK Офтальмохирургия lasik dry eye syndrome cyclosporine corneal flap ablation depth |
| title | Topical application of 0.05% cyclosporine A as an adjunct to LASIK |
| title_full | Topical application of 0.05% cyclosporine A as an adjunct to LASIK |
| title_fullStr | Topical application of 0.05% cyclosporine A as an adjunct to LASIK |
| title_full_unstemmed | Topical application of 0.05% cyclosporine A as an adjunct to LASIK |
| title_short | Topical application of 0.05% cyclosporine A as an adjunct to LASIK |
| title_sort | topical application of 0 05 cyclosporine a as an adjunct to lasik |
| topic | lasik dry eye syndrome cyclosporine corneal flap ablation depth |
| url | https://www.ophthalmosurgery.ru/jour/article/view/192 |
| work_keys_str_mv | AT evkudryashova topicalapplicationof005cyclosporineaasanadjuncttolasik AT dsmaltsev topicalapplicationof005cyclosporineaasanadjuncttolasik |