Loss of p27Kip1 expression in high grade human prostate adenocarcinoma
p27Kip1 has been hypothesized to play a major role in carcinogenesis. Most of the published data reported that loss of p27Kip1 expression was strongly associated with development and progression of tumour. The purpose of this study was to analyze p27Kip1 expression in normal, benign and malignant pr...
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| Format: | Article |
| Language: | English |
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Plovdiv University Press
2014-08-01
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| Series: | Journal of BioScience and Biotechnology |
| Subjects: | |
| Online Access: | http://www.jbb.uni-plovdiv.bg/documents/27807/352486/jbb_2014-3(2)-pages_119-125.pdf |
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| author | MOHD ROHAIZAD MD. RODUAN NORHAFIZAH MOHTARRUDIN CHONG PEI PEI MALINA OSMAN NORAINI MAT DUSA |
| author_facet | MOHD ROHAIZAD MD. RODUAN NORHAFIZAH MOHTARRUDIN CHONG PEI PEI MALINA OSMAN NORAINI MAT DUSA |
| author_sort | MOHD ROHAIZAD MD. RODUAN |
| collection | DOAJ |
| description | p27Kip1 has been hypothesized to play a major role in carcinogenesis. Most of the published data reported that loss of p27Kip1 expression was strongly associated with development and progression of tumour. The purpose of this study was to analyze p27Kip1 expression in normal, benign and malignant prostate cancer tissues and their association with the clinicopathological parameters. The expression of p27Kip1 was evaluated by an immunohistochemistry method. p27Kip1 expression was significantly higher in normal and benign prostate tissues (P<0.01). In contrast, some malignant tissues had no p27Kip1 expression and most had weak p27Kip1 expression. p27Kip1 expression was found to be decreased significantly with increasing Gleason scores (P=0.003). Most of prostate adenocarcinomas (PCa) with Gleason 8 and 9 showed loss of p27Kip1 expression. The expression was also positively correlated with prostate specific antigen level and age in PCa group (P=0.003 and 0.043 respectively), whereas no association was found between the p27Kip1 expression with tumour amount and age in benign prostatic hyperplasia group. This study suggests that loss of p27Kip1expression is essential during development and progression of prostate cancer. |
| first_indexed | 2024-12-14T02:51:10Z |
| format | Article |
| id | doaj.art-d097fc71b9484d379c42e5712db63775 |
| institution | Directory Open Access Journal |
| issn | 1314-6238 1314-6246 |
| language | English |
| last_indexed | 2024-12-14T02:51:10Z |
| publishDate | 2014-08-01 |
| publisher | Plovdiv University Press |
| record_format | Article |
| series | Journal of BioScience and Biotechnology |
| spelling | doaj.art-d097fc71b9484d379c42e5712db637752022-12-21T23:19:45ZengPlovdiv University PressJournal of BioScience and Biotechnology1314-62381314-62462014-08-0132119125Loss of p27Kip1 expression in high grade human prostate adenocarcinomaMOHD ROHAIZAD MD. RODUAN0NORHAFIZAH MOHTARRUDIN1CHONG PEI PEI2MALINA OSMAN3NORAINI MAT DUSA4Department of Pathology Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Pathology Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Biomedical SciencesDepartment of Medical Microbiology & Parasitology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Pathology , Hospital Kuala Lumpur, Jalan Pahang, 50588 Kuala Lumpur, Malaysiap27Kip1 has been hypothesized to play a major role in carcinogenesis. Most of the published data reported that loss of p27Kip1 expression was strongly associated with development and progression of tumour. The purpose of this study was to analyze p27Kip1 expression in normal, benign and malignant prostate cancer tissues and their association with the clinicopathological parameters. The expression of p27Kip1 was evaluated by an immunohistochemistry method. p27Kip1 expression was significantly higher in normal and benign prostate tissues (P<0.01). In contrast, some malignant tissues had no p27Kip1 expression and most had weak p27Kip1 expression. p27Kip1 expression was found to be decreased significantly with increasing Gleason scores (P=0.003). Most of prostate adenocarcinomas (PCa) with Gleason 8 and 9 showed loss of p27Kip1 expression. The expression was also positively correlated with prostate specific antigen level and age in PCa group (P=0.003 and 0.043 respectively), whereas no association was found between the p27Kip1 expression with tumour amount and age in benign prostatic hyperplasia group. This study suggests that loss of p27Kip1expression is essential during development and progression of prostate cancer.http://www.jbb.uni-plovdiv.bg/documents/27807/352486/jbb_2014-3(2)-pages_119-125.pdfcarcinogenesisprostate adenocarcinoma (PCa)benign prostatic hyperplasia (BPH)p27Kip1 |
| spellingShingle | MOHD ROHAIZAD MD. RODUAN NORHAFIZAH MOHTARRUDIN CHONG PEI PEI MALINA OSMAN NORAINI MAT DUSA Loss of p27Kip1 expression in high grade human prostate adenocarcinoma Journal of BioScience and Biotechnology carcinogenesis prostate adenocarcinoma (PCa) benign prostatic hyperplasia (BPH) p27Kip1 |
| title | Loss of p27Kip1 expression in high grade human prostate adenocarcinoma |
| title_full | Loss of p27Kip1 expression in high grade human prostate adenocarcinoma |
| title_fullStr | Loss of p27Kip1 expression in high grade human prostate adenocarcinoma |
| title_full_unstemmed | Loss of p27Kip1 expression in high grade human prostate adenocarcinoma |
| title_short | Loss of p27Kip1 expression in high grade human prostate adenocarcinoma |
| title_sort | loss of p27kip1 expression in high grade human prostate adenocarcinoma |
| topic | carcinogenesis prostate adenocarcinoma (PCa) benign prostatic hyperplasia (BPH) p27Kip1 |
| url | http://www.jbb.uni-plovdiv.bg/documents/27807/352486/jbb_2014-3(2)-pages_119-125.pdf |
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