Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma
AbstractOsteosarcoma is the most common malignant tumor in the skeletal system with high mortality. Phytic acid (PA) is a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop a novel theranostics for magnetic resonance imagin...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2023.2181743 |
| _version_ | 1827317473709391872 |
|---|---|
| author | Qian Ju Rong Huang Ruimin Hu Junjie Fan Dinglin Zhang Jun Ding Rong Li |
| author_facet | Qian Ju Rong Huang Ruimin Hu Junjie Fan Dinglin Zhang Jun Ding Rong Li |
| author_sort | Qian Ju |
| collection | DOAJ |
| description | AbstractOsteosarcoma is the most common malignant tumor in the skeletal system with high mortality. Phytic acid (PA) is a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop a novel theranostics for magnetic resonance imaging (MRI) and targeting therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles (MnO2@PA NPs) for osteosarcoma treatment. The MnO2 NPs oligomer was formed by PA modification with uniformed size distribution and negative zeta potential. Fourier-transform infrared spectroscopy, X-ray diffraction, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis demonstrated that PA has been successfully modified on MnO2 NPs, and the structure of MnO2@PA NPs is amorphous. In vitro experiments demonstrated that MnO2@PA NPs oligomer can be efficiently internalized by tumor cell, and the internalized NPs can react with H2O2 under acid microenvironment to produce Mn2+ and O2. In vivo experiments demonstrated that MnO2@PA NPs oligomer can passively accumulate in tumor tissue, and the accumulated NPs can produce Mn2+ and O2 for MRI and targeting therapy of osteosarcoma. In conclusion, we prepared a novel bone-targeting nano theranostics for MRI and therapy of osteosarcoma. |
| first_indexed | 2024-03-08T23:31:07Z |
| format | Article |
| id | doaj.art-d098b3580c724e868fa7d7cdd697e100 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-24T23:33:42Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-d098b3580c724e868fa7d7cdd697e1002024-03-15T14:22:17ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642023-12-0130110.1080/10717544.2023.2181743Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcomaQian Ju0Rong Huang1Ruimin Hu2Junjie Fan3Dinglin Zhang4Jun Ding5Rong Li6College of Chemistry, Chongqing Normal University, Chongqing, ChinaDepartment of Chemistry, College of Basic Medicine, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Urology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Clinical Laboratory, the 958th Hospital of Chinese People’s Liberation Army, Chongqing, ChinaDepartment of Chemistry, College of Basic Medicine, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Ultrasonics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaCollege of Chemistry, Chongqing Normal University, Chongqing, ChinaAbstractOsteosarcoma is the most common malignant tumor in the skeletal system with high mortality. Phytic acid (PA) is a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop a novel theranostics for magnetic resonance imaging (MRI) and targeting therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles (MnO2@PA NPs) for osteosarcoma treatment. The MnO2 NPs oligomer was formed by PA modification with uniformed size distribution and negative zeta potential. Fourier-transform infrared spectroscopy, X-ray diffraction, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis demonstrated that PA has been successfully modified on MnO2 NPs, and the structure of MnO2@PA NPs is amorphous. In vitro experiments demonstrated that MnO2@PA NPs oligomer can be efficiently internalized by tumor cell, and the internalized NPs can react with H2O2 under acid microenvironment to produce Mn2+ and O2. In vivo experiments demonstrated that MnO2@PA NPs oligomer can passively accumulate in tumor tissue, and the accumulated NPs can produce Mn2+ and O2 for MRI and targeting therapy of osteosarcoma. In conclusion, we prepared a novel bone-targeting nano theranostics for MRI and therapy of osteosarcoma.https://www.tandfonline.com/doi/10.1080/10717544.2023.2181743Phytic acidmanganese dioxide nanoparticlesosteosarcomamagnetic resonance imagingtargeting therapy |
| spellingShingle | Qian Ju Rong Huang Ruimin Hu Junjie Fan Dinglin Zhang Jun Ding Rong Li Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma Drug Delivery Phytic acid manganese dioxide nanoparticles osteosarcoma magnetic resonance imaging targeting therapy |
| title | Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma |
| title_full | Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma |
| title_fullStr | Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma |
| title_full_unstemmed | Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma |
| title_short | Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma |
| title_sort | phytic acid modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma |
| topic | Phytic acid manganese dioxide nanoparticles osteosarcoma magnetic resonance imaging targeting therapy |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2023.2181743 |
| work_keys_str_mv | AT qianju phyticacidmodifiedmanganesedioxidenanoparticlesoligomerformagneticresonanceimagingandtargetingtherapyofosteosarcoma AT ronghuang phyticacidmodifiedmanganesedioxidenanoparticlesoligomerformagneticresonanceimagingandtargetingtherapyofosteosarcoma AT ruiminhu phyticacidmodifiedmanganesedioxidenanoparticlesoligomerformagneticresonanceimagingandtargetingtherapyofosteosarcoma AT junjiefan phyticacidmodifiedmanganesedioxidenanoparticlesoligomerformagneticresonanceimagingandtargetingtherapyofosteosarcoma AT dinglinzhang phyticacidmodifiedmanganesedioxidenanoparticlesoligomerformagneticresonanceimagingandtargetingtherapyofosteosarcoma AT junding phyticacidmodifiedmanganesedioxidenanoparticlesoligomerformagneticresonanceimagingandtargetingtherapyofosteosarcoma AT rongli phyticacidmodifiedmanganesedioxidenanoparticlesoligomerformagneticresonanceimagingandtargetingtherapyofosteosarcoma |