Cooperation between cGAS and RIG-I sensing pathways enables improved innate recognition of HIV-1 by myeloid dendritic cells in elite controllers

Cooperation between cGAS and RIG-I sensing pathways enables improved innate recognition of HIV-1 by myeloid dendritic cells in elite controllers

IntroductionSpontaneous control of HIV-1 replication in the absence of anti-retroviral therapy (ART) naturally occurs in a small proportion of HIV-1-infected individuals known as elite controllers (EC), likely as a result of improved innate and adaptive immune mechanisms. Previous studies suggest th...

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Bibliographic Details
Main Authors: Enrique Martin-Gayo, Ce Gao, Marta Calvet-Mirabent, Zhengyu Ouyang, Mathias Lichterfeld, Xu G. Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
HIV-1
innate immunity
myeloid dendritic cells
DNA sensor
RNA sensor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1017164/full

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