mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases
In the prevention and treatment of infectious diseases, mRNA vaccines hold great promise because of their low risk of insertional mutagenesis, high potency, accelerated development cycles, and potential for low-cost manufacture. In past years, several mRNA vaccines have entered clinical trials and h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/2/401 |
| _version_ | 1797476019205046272 |
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| author | Ting Le Chao Sun Jitao Chang Guijie Zhang Xin Yin |
| author_facet | Ting Le Chao Sun Jitao Chang Guijie Zhang Xin Yin |
| author_sort | Ting Le |
| collection | DOAJ |
| description | In the prevention and treatment of infectious diseases, mRNA vaccines hold great promise because of their low risk of insertional mutagenesis, high potency, accelerated development cycles, and potential for low-cost manufacture. In past years, several mRNA vaccines have entered clinical trials and have shown promise for offering solutions to combat emerging and re-emerging infectious diseases such as rabies, Zika, and influenza. Recently, the successful application of mRNA vaccines against COVID-19 has further validated the platform and opened the floodgates to mRNA vaccine’s potential in infectious disease prevention, especially in the veterinary field. In this review, we describe our current understanding of the mRNA vaccines and the technologies used for mRNA vaccine development. We also provide an overview of mRNA vaccines developed for animal infectious diseases and discuss directions and challenges for the future applications of this promising vaccine platform in the veterinary field. |
| first_indexed | 2024-03-09T20:51:57Z |
| format | Article |
| id | doaj.art-d09972c44b8f43719f5a69588da90973 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T20:51:57Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d09972c44b8f43719f5a69588da909732023-11-23T22:32:18ZengMDPI AGViruses1999-49152022-02-0114240110.3390/v14020401mRNA Vaccine Development for Emerging Animal and Zoonotic DiseasesTing Le0Chao Sun1Jitao Chang2Guijie Zhang3Xin Yin4State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaDepartments of Animal Science, School of Agriculture, Ningxia University, Yinchuan 750021, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaIn the prevention and treatment of infectious diseases, mRNA vaccines hold great promise because of their low risk of insertional mutagenesis, high potency, accelerated development cycles, and potential for low-cost manufacture. In past years, several mRNA vaccines have entered clinical trials and have shown promise for offering solutions to combat emerging and re-emerging infectious diseases such as rabies, Zika, and influenza. Recently, the successful application of mRNA vaccines against COVID-19 has further validated the platform and opened the floodgates to mRNA vaccine’s potential in infectious disease prevention, especially in the veterinary field. In this review, we describe our current understanding of the mRNA vaccines and the technologies used for mRNA vaccine development. We also provide an overview of mRNA vaccines developed for animal infectious diseases and discuss directions and challenges for the future applications of this promising vaccine platform in the veterinary field.https://www.mdpi.com/1999-4915/14/2/401mRNA vaccineinfectious diseasezoonosesimmune responseviruses |
| spellingShingle | Ting Le Chao Sun Jitao Chang Guijie Zhang Xin Yin mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases Viruses mRNA vaccine infectious disease zoonoses immune response viruses |
| title | mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases |
| title_full | mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases |
| title_fullStr | mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases |
| title_full_unstemmed | mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases |
| title_short | mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases |
| title_sort | mrna vaccine development for emerging animal and zoonotic diseases |
| topic | mRNA vaccine infectious disease zoonoses immune response viruses |
| url | https://www.mdpi.com/1999-4915/14/2/401 |
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