Development of Non-Ethoxypropanoic Acid Type Cryptochrome Inhibitors with Circadian Molecular Clock-Enhancing Activity by Bioisosteric Replacement

Development of Non-Ethoxypropanoic Acid Type Cryptochrome Inhibitors with Circadian Molecular Clock-Enhancing Activity by Bioisosteric Replacement

Circadian dysfunction is closely associated with an increased risk of various diseases. Considering that molecular clock machinery serves as an intrinsic time-keeping system underlying the circadian rhythm of biological processes, the modulation of the molecular clock machinery is an attractive ther...

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Bibliographic Details
Main Authors: Yong Uk Jeong, Hyo-Eon Jin, Hye Young Lim, Goyeong Choi, Hansol Joo, Bohun Kang, Ga-Hyun Lee, Kwang-Hyeon Liu, Han-Joo Maeng, Sooyoung Chung, Gi Hoon Son, Jong-Wha Jung
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
circadian rhythm
circadian clock
cryptochrome inhibitor
bioisosteric replacement
Online Access:https://www.mdpi.com/1424-8247/14/6/496

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