| Summary: | Objectives:The aim of this study is to identify the shared similar characteristics of tympanosclerosis and atherosclerosis on light and electron microscopy and to find out if there is a genetic predisposition between these two conditions.Methods:Tympanosclerotic materials were taken from 7 patients who were operated on due to chronic otitis media and atherosclerotic materials were taken from 4 patients on whom coronary arterial bypass grafting operations had been performed. Tympanosclerotic and atherosclerotic specimens were examined under light and electron microscopy.Results:In the examination of the specimens, the important common characteristics in both specimen groups were increase in collagen fibers, presence of calcified areas, increase of the infectious cells and especially the fibroblasts.Conclusion:In tympanosclerosis and atherosclerosis, the basic mechanism of the reaction goes through the same routes. Both the ultrastructural similarities between atherosclerosis and tympanosclerosis as well as the sexual difference seen in each of the two diseases, in addition to the incidence of tympanosclerosis observed on atherosclerotic patients in comparison to the normal population, is indicating that the genetic-familial predisposition of sclerotic changes is shared by all tissues, and that tympanosclerosis must be the appearance of the same genetic characteristic in the middle ear.
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