Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases
Abstract Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. Rheumatologists have been using antimalarials to manage patients with chroni...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Advances in Rheumatology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s42358-020-00134-8 |
| _version_ | 1818318457548046336 |
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| author | Edgard Torres dos Reis Neto Adriana Maria Kakehasi Marcelo de Medeiros Pinheiro Gilda Aparecida Ferreira Cláudia Diniz Lopes Marques Licia Maria Henrique da Mota Eduardo dos Santos Paiva Gecilmara Cristina Salviato Pileggi Emília Inoue Sato Ana Paula Monteiro Gomides Reis Ricardo Machado Xavier José Roberto Provenza |
| author_facet | Edgard Torres dos Reis Neto Adriana Maria Kakehasi Marcelo de Medeiros Pinheiro Gilda Aparecida Ferreira Cláudia Diniz Lopes Marques Licia Maria Henrique da Mota Eduardo dos Santos Paiva Gecilmara Cristina Salviato Pileggi Emília Inoue Sato Ana Paula Monteiro Gomides Reis Ricardo Machado Xavier José Roberto Provenza |
| author_sort | Edgard Torres dos Reis Neto |
| collection | DOAJ |
| description | Abstract Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. Rheumatologists have been using antimalarials to manage patients with chronic immune-mediated inflammatory rheumatic diseases for decades. It is an appropriate time to review their immunomodulatory and anti-inflammatory mechanisms impact on disease activity and survival of systemic lupus erythematosus patient, including antiplatelet effect, metabolic and lipid benefits. We also discuss possible adverse effects, adding a practical and comprehensive approach to monitoring rheumatic patients during treatment with these drugs. |
| first_indexed | 2024-12-13T09:53:31Z |
| format | Article |
| id | doaj.art-d09aba9e0d2642d680c8ab33ea916663 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-12-13T09:53:31Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-d09aba9e0d2642d680c8ab33ea9166632022-12-21T23:51:52ZengBMCAdvances in Rheumatology2523-31062020-06-0160111110.1186/s42358-020-00134-8Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseasesEdgard Torres dos Reis Neto0Adriana Maria Kakehasi1Marcelo de Medeiros Pinheiro2Gilda Aparecida Ferreira3Cláudia Diniz Lopes Marques4Licia Maria Henrique da Mota5Eduardo dos Santos Paiva6Gecilmara Cristina Salviato Pileggi7Emília Inoue Sato8Ana Paula Monteiro Gomides Reis9Ricardo Machado Xavier10José Roberto Provenza11Disciplina de Reumatologia, Escola Paulista de Medicina, Universidade Federal de São PauloServiço de Reumatologia do Hospital das Clínicas da Universidade Federal de Minas GeraisDisciplina de Reumatologia, Escola Paulista de Medicina, Universidade Federal de São PauloServiço de Reumatologia do Hospital das Clínicas da Universidade Federal de Minas GeraisServiço de Reumatologia do Hospital das Clínicas da Universidade Federal de PernambucoHospital Universitário - UnB/EBSERHServiço de Reumatologia do Hospital das Clínicas da Universidade Federal do ParanáInstituto de Ensino e Pesquisa (IEP), Hospital AmorDisciplina de Reumatologia, Escola Paulista de Medicina, Universidade Federal de São PauloHospital Universitário - UnB/EBSERHServiço de Reumatologia do Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do SulPontifícia Universidade Católica de CampinasAbstract Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. Rheumatologists have been using antimalarials to manage patients with chronic immune-mediated inflammatory rheumatic diseases for decades. It is an appropriate time to review their immunomodulatory and anti-inflammatory mechanisms impact on disease activity and survival of systemic lupus erythematosus patient, including antiplatelet effect, metabolic and lipid benefits. We also discuss possible adverse effects, adding a practical and comprehensive approach to monitoring rheumatic patients during treatment with these drugs.http://link.springer.com/article/10.1186/s42358-020-00134-8HydroxychloroquineChloroquineAntimalarialsChronic immune-mediated inflammatory rheumatic diseases |
| spellingShingle | Edgard Torres dos Reis Neto Adriana Maria Kakehasi Marcelo de Medeiros Pinheiro Gilda Aparecida Ferreira Cláudia Diniz Lopes Marques Licia Maria Henrique da Mota Eduardo dos Santos Paiva Gecilmara Cristina Salviato Pileggi Emília Inoue Sato Ana Paula Monteiro Gomides Reis Ricardo Machado Xavier José Roberto Provenza Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases Advances in Rheumatology Hydroxychloroquine Chloroquine Antimalarials Chronic immune-mediated inflammatory rheumatic diseases |
| title | Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases |
| title_full | Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases |
| title_fullStr | Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases |
| title_full_unstemmed | Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases |
| title_short | Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases |
| title_sort | revisiting hydroxychloroquine and chloroquine for patients with chronic immunity mediated inflammatory rheumatic diseases |
| topic | Hydroxychloroquine Chloroquine Antimalarials Chronic immune-mediated inflammatory rheumatic diseases |
| url | http://link.springer.com/article/10.1186/s42358-020-00134-8 |
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