The Effect of Venoactive Drug Therapy on the Development and Severity of Post-Embolization Syndrome in Endovascular Interventions on the Gonadal Veins
<b>Objective.</b> To evaluate the incidence of post-embolization syndrome (PES) and the effect of venoactive therapy on its development, severity, and duration after endovascular embolization of gonadal veins (EEGV) with coils in patients with pelvic congestion syndrome (PCS). <b>M...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/6/521 |
| _version_ | 1797531191979540480 |
|---|---|
| author | Sergey Gennadievich Gavrilov Gennady Vladimirovich Krasavin Nadezhda Yurievna Mishakina Oksana Igorevna Efremova Igor Anatolievich Zolotukhin |
| author_facet | Sergey Gennadievich Gavrilov Gennady Vladimirovich Krasavin Nadezhda Yurievna Mishakina Oksana Igorevna Efremova Igor Anatolievich Zolotukhin |
| author_sort | Sergey Gennadievich Gavrilov |
| collection | DOAJ |
| description | <b>Objective.</b> To evaluate the incidence of post-embolization syndrome (PES) and the effect of venoactive therapy on its development, severity, and duration after endovascular embolization of gonadal veins (EEGV) with coils in patients with pelvic congestion syndrome (PCS). <b>Materials and Methods.</b> We analyzed the outcomes of EEGV with coils in 70 female patients who received (<i>n</i> = 38; group 1) or did not receive (<i>n</i> = 32; group 2) treatment with a venoactive drug (VAD) before and after the procedure. Assessments of the EEGV efficacy and for possible signs of PES were done on days 1, 5, 10, 15, 20, and 30 after the intervention. All patients underwent transvaginal and transabdominal duplex ultrasound scanning (DUS) after EEGV. In addition, patients with PES were examined using the computed tomography of the pelvic veins in the postprocedural period. <b>Results.</b> Technical success of EEGV was achieved in 100% of patients. Pelvic venous pain (PVP) reduction after EEGV was observed in 77.1% of patients. The PES was diagnosed in 18.6% of cases (10.5% in group 1 vs. 28.1% in group 2, <i>p</i> > 0.05). In three patients of group 1, the protrusion of coils was suspected and eventually verified during the resection of the left gonadal vein with coils. The group 1 patients had less severe post-embolization pain (6.2 ± 0.4 vs. 7.8 ± 0.3 scores in group 2; <i>p</i> = 0.009) and three times shorter duration of PES (5.0 ± 1.2 vs. 16.2 ± 2.7 days; <i>p</i> = 0.003). No significant differences in the diameters of gonadal veins, side of embolization, and number of coils were revealed between patients with and without PES. The rate of parametrium vein thrombosis was found to be significantly higher in patients with PES than in those without PES (30.7% vs. 18.5%, respectively; <i>p</i> < 0.05). <b>Conclusion.</b> The PES is a frequent complication of EEGV with coils and occurs in 18.6% of patients. Venoactive treatment does not effect the incidence of this complication but reduces the PES severity and duration. |
| first_indexed | 2024-03-10T10:40:24Z |
| format | Article |
| id | doaj.art-d09b3cdfb6cc47f696210256b045b3a2 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T10:40:24Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-d09b3cdfb6cc47f696210256b045b3a22023-11-21T23:02:16ZengMDPI AGJournal of Personalized Medicine2075-44262021-06-0111652110.3390/jpm11060521The Effect of Venoactive Drug Therapy on the Development and Severity of Post-Embolization Syndrome in Endovascular Interventions on the Gonadal VeinsSergey Gennadievich Gavrilov0Gennady Vladimirovich Krasavin1Nadezhda Yurievna Mishakina2Oksana Igorevna Efremova3Igor Anatolievich Zolotukhin4Department of Fundamental and Applied Research in Surgery, Pirogov Russian National Research Medical University, 10/5 Leninsky Prospect, 119049 Moscow, RussiaDepartment of Fundamental and Applied Research in Surgery, Pirogov Russian National Research Medical University, 10/5 Leninsky Prospect, 119049 Moscow, RussiaDepartment of Fundamental and Applied Research in Surgery, Pirogov Russian National Research Medical University, 10/5 Leninsky Prospect, 119049 Moscow, RussiaDepartment of Fundamental and Applied Research in Surgery, Pirogov Russian National Research Medical University, 10/5 Leninsky Prospect, 119049 Moscow, RussiaDepartment of Fundamental and Applied Research in Surgery, Pirogov Russian National Research Medical University, 10/5 Leninsky Prospect, 119049 Moscow, Russia<b>Objective.</b> To evaluate the incidence of post-embolization syndrome (PES) and the effect of venoactive therapy on its development, severity, and duration after endovascular embolization of gonadal veins (EEGV) with coils in patients with pelvic congestion syndrome (PCS). <b>Materials and Methods.</b> We analyzed the outcomes of EEGV with coils in 70 female patients who received (<i>n</i> = 38; group 1) or did not receive (<i>n</i> = 32; group 2) treatment with a venoactive drug (VAD) before and after the procedure. Assessments of the EEGV efficacy and for possible signs of PES were done on days 1, 5, 10, 15, 20, and 30 after the intervention. All patients underwent transvaginal and transabdominal duplex ultrasound scanning (DUS) after EEGV. In addition, patients with PES were examined using the computed tomography of the pelvic veins in the postprocedural period. <b>Results.</b> Technical success of EEGV was achieved in 100% of patients. Pelvic venous pain (PVP) reduction after EEGV was observed in 77.1% of patients. The PES was diagnosed in 18.6% of cases (10.5% in group 1 vs. 28.1% in group 2, <i>p</i> > 0.05). In three patients of group 1, the protrusion of coils was suspected and eventually verified during the resection of the left gonadal vein with coils. The group 1 patients had less severe post-embolization pain (6.2 ± 0.4 vs. 7.8 ± 0.3 scores in group 2; <i>p</i> = 0.009) and three times shorter duration of PES (5.0 ± 1.2 vs. 16.2 ± 2.7 days; <i>p</i> = 0.003). No significant differences in the diameters of gonadal veins, side of embolization, and number of coils were revealed between patients with and without PES. The rate of parametrium vein thrombosis was found to be significantly higher in patients with PES than in those without PES (30.7% vs. 18.5%, respectively; <i>p</i> < 0.05). <b>Conclusion.</b> The PES is a frequent complication of EEGV with coils and occurs in 18.6% of patients. Venoactive treatment does not effect the incidence of this complication but reduces the PES severity and duration.https://www.mdpi.com/2075-4426/11/6/521pelvic congestion syndromeendovascular embolization of the gonadal veinspost-embolization syndromevenoactive drug |
| spellingShingle | Sergey Gennadievich Gavrilov Gennady Vladimirovich Krasavin Nadezhda Yurievna Mishakina Oksana Igorevna Efremova Igor Anatolievich Zolotukhin The Effect of Venoactive Drug Therapy on the Development and Severity of Post-Embolization Syndrome in Endovascular Interventions on the Gonadal Veins Journal of Personalized Medicine pelvic congestion syndrome endovascular embolization of the gonadal veins post-embolization syndrome venoactive drug |
| title | The Effect of Venoactive Drug Therapy on the Development and Severity of Post-Embolization Syndrome in Endovascular Interventions on the Gonadal Veins |
| title_full | The Effect of Venoactive Drug Therapy on the Development and Severity of Post-Embolization Syndrome in Endovascular Interventions on the Gonadal Veins |
| title_fullStr | The Effect of Venoactive Drug Therapy on the Development and Severity of Post-Embolization Syndrome in Endovascular Interventions on the Gonadal Veins |
| title_full_unstemmed | The Effect of Venoactive Drug Therapy on the Development and Severity of Post-Embolization Syndrome in Endovascular Interventions on the Gonadal Veins |
| title_short | The Effect of Venoactive Drug Therapy on the Development and Severity of Post-Embolization Syndrome in Endovascular Interventions on the Gonadal Veins |
| title_sort | effect of venoactive drug therapy on the development and severity of post embolization syndrome in endovascular interventions on the gonadal veins |
| topic | pelvic congestion syndrome endovascular embolization of the gonadal veins post-embolization syndrome venoactive drug |
| url | https://www.mdpi.com/2075-4426/11/6/521 |
| work_keys_str_mv | AT sergeygennadievichgavrilov theeffectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT gennadyvladimirovichkrasavin theeffectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT nadezhdayurievnamishakina theeffectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT oksanaigorevnaefremova theeffectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT igoranatolievichzolotukhin theeffectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT sergeygennadievichgavrilov effectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT gennadyvladimirovichkrasavin effectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT nadezhdayurievnamishakina effectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT oksanaigorevnaefremova effectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins AT igoranatolievichzolotukhin effectofvenoactivedrugtherapyonthedevelopmentandseverityofpostembolizationsyndromeinendovascularinterventionsonthegonadalveins |