Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward
Despite the overlapping neural circuits underlying natural and drug rewards, several studies have suggested different behavioral and neurochemical mechanisms in response to drug vs. natural rewards. The strong link between hippocampal theta oscillations (4–12 Hz) and reward-associated learning and m...
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MDPI AG
2023-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/2/322 |
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| author | Shole Jamali Mohsen Parto Dezfouli AmirAli Kalbasi Mohammad Reza Daliri Abbas Haghparast |
| author_facet | Shole Jamali Mohsen Parto Dezfouli AmirAli Kalbasi Mohammad Reza Daliri Abbas Haghparast |
| author_sort | Shole Jamali |
| collection | DOAJ |
| description | Despite the overlapping neural circuits underlying natural and drug rewards, several studies have suggested different behavioral and neurochemical mechanisms in response to drug vs. natural rewards. The strong link between hippocampal theta oscillations (4–12 Hz) and reward-associated learning and memory has raised the hypothesis that this rhythm in hippocampal CA1 might be differently modulated by drug- and natural-conditioned place preference (CPP). Time–frequency analysis of recorded local field potentials (LFPs) from the CA1 of freely moving male rats previously exposed to a natural (in this case, food), drug (in this case, morphine), or saline (control) reward cue in the CPP paradigm showed that the hippocampal CA1 theta activity represents a different pattern for entrance to the rewarded compared to unrewarded compartment during the post-test session of morphine- and natural-CPP. Comparing LFP activity in the CA1 between the saline and morphine/natural groups showed that the maximum theta power occurred before entering the unrewarded compartment and after the entrance to the rewarded compartment in morphine and natural groups, respectively. In conclusion, our findings suggest that drug and natural rewards could differently affect the theta dynamic in the hippocampal CA1 region during reward-associated learning and contextual cueing in the CPP paradigm. |
| first_indexed | 2024-03-11T09:04:27Z |
| format | Article |
| id | doaj.art-d09b3e09cc034760ad6a5ecc1aac1d14 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T09:04:27Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d09b3e09cc034760ad6a5ecc1aac1d142023-11-16T19:29:25ZengMDPI AGBrain Sciences2076-34252023-02-0113232210.3390/brainsci13020322Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural RewardShole Jamali0Mohsen Parto Dezfouli1AmirAli Kalbasi2Mohammad Reza Daliri3Abbas Haghparast4Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 19615-1178, IranSchool of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran P.O. Box 19395-5531, IranDepartment of Mechatronics, Faculty of Electrical Engineering, K. N. Toosi University of Technology, Tehran P.O. Box 16315-1355, IranSchool of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran P.O. Box 19395-5531, IranNeuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 19615-1178, IranDespite the overlapping neural circuits underlying natural and drug rewards, several studies have suggested different behavioral and neurochemical mechanisms in response to drug vs. natural rewards. The strong link between hippocampal theta oscillations (4–12 Hz) and reward-associated learning and memory has raised the hypothesis that this rhythm in hippocampal CA1 might be differently modulated by drug- and natural-conditioned place preference (CPP). Time–frequency analysis of recorded local field potentials (LFPs) from the CA1 of freely moving male rats previously exposed to a natural (in this case, food), drug (in this case, morphine), or saline (control) reward cue in the CPP paradigm showed that the hippocampal CA1 theta activity represents a different pattern for entrance to the rewarded compared to unrewarded compartment during the post-test session of morphine- and natural-CPP. Comparing LFP activity in the CA1 between the saline and morphine/natural groups showed that the maximum theta power occurred before entering the unrewarded compartment and after the entrance to the rewarded compartment in morphine and natural groups, respectively. In conclusion, our findings suggest that drug and natural rewards could differently affect the theta dynamic in the hippocampal CA1 region during reward-associated learning and contextual cueing in the CPP paradigm.https://www.mdpi.com/2076-3425/13/2/322rewardfoodmorphinehippocampal CA1 regionlocal field potentialtheta oscillations |
| spellingShingle | Shole Jamali Mohsen Parto Dezfouli AmirAli Kalbasi Mohammad Reza Daliri Abbas Haghparast Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward Brain Sciences reward food morphine hippocampal CA1 region local field potential theta oscillations |
| title | Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward |
| title_full | Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward |
| title_fullStr | Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward |
| title_full_unstemmed | Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward |
| title_short | Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward |
| title_sort | selective modulation of hippocampal theta oscillations in response to morphine versus natural reward |
| topic | reward food morphine hippocampal CA1 region local field potential theta oscillations |
| url | https://www.mdpi.com/2076-3425/13/2/322 |
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