Cadmium exposure and its association with serum uric acid and hyperuricemia
Abstract Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is a...
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Nature Portfolio
2017-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-00661-3 |
| _version_ | 1819036339839959040 |
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| author | Honglin Sun Ningjian Wang Chi Chen Xiaomin Nie Bing Han Qin Li Chunfang Zhu Yi Chen Fangzhen Xia Yingchao Chen Hualing Zhai Boren Jiang Bin Hu Yingli Lu |
| author_facet | Honglin Sun Ningjian Wang Chi Chen Xiaomin Nie Bing Han Qin Li Chunfang Zhu Yi Chen Fangzhen Xia Yingchao Chen Hualing Zhai Boren Jiang Bin Hu Yingli Lu |
| author_sort | Honglin Sun |
| collection | DOAJ |
| description | Abstract Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is associated with serum UA and hyperuricemia, 2996 participants from the cross-sectional SPECT-China study were recruited. CdB was measured by atomic absorption spectrometry. Hyperuricemia was defined as a serum UA concentration ≥416.4 μmol/L for men and ≥356.9 μmol/L for women. Regression analyses were used to analyze the association of CdB with serum UA and hyperuricemia. We found that the median CdB level was higher in men with hyperuricemia (2.40 μg/L) than in men without hyperuricemia (1.98 μg/L, P < 0.05). A positive relationship between serum UA and CdB was found in Chinese men after adjusting for the estimated glomerular filtration rate (eGFR), current smoking status, diabetes, dyslipidemia, hypertension and body mass index and in participants with eGFR > 60 mL/min per 1.73 m2. Further, the odds ratio of hyperuricemia increased with increasing CdB quartiles (P for trend < 0.05) in men. In conclusion, CdB was positively related to the serum UA level and to hyperuricemia in Chinese men but not in Chinese women. |
| first_indexed | 2024-12-21T08:03:57Z |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T08:03:57Z |
| publishDate | 2017-04-01 |
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| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d09d7451b71c4b50bc70052933a73dbb2022-12-21T19:10:51ZengNature PortfolioScientific Reports2045-23222017-04-01711810.1038/s41598-017-00661-3Cadmium exposure and its association with serum uric acid and hyperuricemiaHonglin Sun0Ningjian Wang1Chi Chen2Xiaomin Nie3Bing Han4Qin Li5Chunfang Zhu6Yi Chen7Fangzhen Xia8Yingchao Chen9Hualing Zhai10Boren Jiang11Bin Hu12Yingli Lu13Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineAbstract Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is associated with serum UA and hyperuricemia, 2996 participants from the cross-sectional SPECT-China study were recruited. CdB was measured by atomic absorption spectrometry. Hyperuricemia was defined as a serum UA concentration ≥416.4 μmol/L for men and ≥356.9 μmol/L for women. Regression analyses were used to analyze the association of CdB with serum UA and hyperuricemia. We found that the median CdB level was higher in men with hyperuricemia (2.40 μg/L) than in men without hyperuricemia (1.98 μg/L, P < 0.05). A positive relationship between serum UA and CdB was found in Chinese men after adjusting for the estimated glomerular filtration rate (eGFR), current smoking status, diabetes, dyslipidemia, hypertension and body mass index and in participants with eGFR > 60 mL/min per 1.73 m2. Further, the odds ratio of hyperuricemia increased with increasing CdB quartiles (P for trend < 0.05) in men. In conclusion, CdB was positively related to the serum UA level and to hyperuricemia in Chinese men but not in Chinese women.https://doi.org/10.1038/s41598-017-00661-3 |
| spellingShingle | Honglin Sun Ningjian Wang Chi Chen Xiaomin Nie Bing Han Qin Li Chunfang Zhu Yi Chen Fangzhen Xia Yingchao Chen Hualing Zhai Boren Jiang Bin Hu Yingli Lu Cadmium exposure and its association with serum uric acid and hyperuricemia Scientific Reports |
| title | Cadmium exposure and its association with serum uric acid and hyperuricemia |
| title_full | Cadmium exposure and its association with serum uric acid and hyperuricemia |
| title_fullStr | Cadmium exposure and its association with serum uric acid and hyperuricemia |
| title_full_unstemmed | Cadmium exposure and its association with serum uric acid and hyperuricemia |
| title_short | Cadmium exposure and its association with serum uric acid and hyperuricemia |
| title_sort | cadmium exposure and its association with serum uric acid and hyperuricemia |
| url | https://doi.org/10.1038/s41598-017-00661-3 |
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