Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice.

Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice.

Androgen receptor (AR) is commonly expressed in both the epithelium of normal mammary glands and in breast cancers. AR expression in breast cancers is independent of estrogen receptor alpha (ERα) status and is frequently associated with overexpression of the ERBB2 oncogene. AR signaling effects on b...

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Bibliographic Details
Main Authors: Myles C Hodgson, Garrett Vanostran, Sarah Alghamdi, Robert J Poppiti, Alexander I Agoulnik, Irina U Agoulnik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3620158?pdf=render

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