The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review
The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigene...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9130 |
| _version_ | 1797597505345552384 |
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| author | Klaudia Dopytalska Anna Czaplicka Elżbieta Szymańska Irena Walecka |
| author_facet | Klaudia Dopytalska Anna Czaplicka Elżbieta Szymańska Irena Walecka |
| author_sort | Klaudia Dopytalska |
| collection | DOAJ |
| description | The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigenetic factors. miRNAs have a significant role in the regulation of the immune response by participating in the process of the differentiation and activation of B and T lymphocytes, macrophages, and dendritic cells. Recent advances in research on epigenetic factors have provided new insights into the pathogenesis and potential diagnostic and therapeutic targets of many pathologies. Numerous studies revealed a change in the expression of some microRNAs in inflammatory skin disorders, and the regulation of miRNA expression is a promising therapeutic goal. This review presents the state of the art regarding changes in the expression and role of miRNAs in inflammatory and autoimmune skin diseases, including psoriasis, atopic dermatitis, vitiligo, lichen planus, hidradenitis suppurativa, and autoimmune blistering diseases. |
| first_indexed | 2024-03-11T03:06:59Z |
| format | Article |
| id | doaj.art-d0a10bc78fd64b86aefaf99df6301c5f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:06:59Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d0a10bc78fd64b86aefaf99df6301c5f2023-11-18T07:54:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411913010.3390/ijms24119130The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A ReviewKlaudia Dopytalska0Anna Czaplicka1Elżbieta Szymańska2Irena Walecka3Department of Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, PolandDepartment of Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, PolandDepartment of Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, PolandDepartment of Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, PolandThe etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigenetic factors. miRNAs have a significant role in the regulation of the immune response by participating in the process of the differentiation and activation of B and T lymphocytes, macrophages, and dendritic cells. Recent advances in research on epigenetic factors have provided new insights into the pathogenesis and potential diagnostic and therapeutic targets of many pathologies. Numerous studies revealed a change in the expression of some microRNAs in inflammatory skin disorders, and the regulation of miRNA expression is a promising therapeutic goal. This review presents the state of the art regarding changes in the expression and role of miRNAs in inflammatory and autoimmune skin diseases, including psoriasis, atopic dermatitis, vitiligo, lichen planus, hidradenitis suppurativa, and autoimmune blistering diseases.https://www.mdpi.com/1422-0067/24/11/9130microRNAskin diseaseautoimmune diseasepsoriasisatopic dermatitishidradenitis suppurativa |
| spellingShingle | Klaudia Dopytalska Anna Czaplicka Elżbieta Szymańska Irena Walecka The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review International Journal of Molecular Sciences microRNA skin disease autoimmune disease psoriasis atopic dermatitis hidradenitis suppurativa |
| title | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
| title_full | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
| title_fullStr | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
| title_full_unstemmed | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
| title_short | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
| title_sort | essential role of micrornas in inflammatory and autoimmune skin diseases a review |
| topic | microRNA skin disease autoimmune disease psoriasis atopic dermatitis hidradenitis suppurativa |
| url | https://www.mdpi.com/1422-0067/24/11/9130 |
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