Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex

Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex

Abstract Background Enterobacter cloacae complex (ECC) is a common opportunistic pathogen and is responsible for causing various infections in humans. Owing to its inducible chromosomal AmpC β-lactamase (AmpC), ECC is inherently resistant to the 1st- and 2nd- generation cephalosporins. However, whet...

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Bibliographic Details
Main Authors: Xianggui Yang, Zhenguo Wang, Mingquan Liu, Xuejing Yu, Yuanxiu Zhong, Fuying Wang, Ying Xu
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Microbiology
Subjects:
Cefazolin
Imipenem
AmpC
NagZ
Enterobacter cloacae complex
Online Access:https://doi.org/10.1186/s12866-022-02707-7

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