A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases
Abstract Breast cancer is the most commonly diagnosed cancer in women worldwide. Approximately one-tenth of all patients with advanced breast cancer develop brain metastases resulting in an overall survival rate of fewer than 2 years. The challenges lie in developing new approaches to treat, monitor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-021-00326-5 |
| _version_ | 1797643086385381376 |
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| author | Natalie S. Joe Christine Hodgdon Lianne Kraemer Kristin J. Redmond Vered Stearns Daniele M. Gilkes |
| author_facet | Natalie S. Joe Christine Hodgdon Lianne Kraemer Kristin J. Redmond Vered Stearns Daniele M. Gilkes |
| author_sort | Natalie S. Joe |
| collection | DOAJ |
| description | Abstract Breast cancer is the most commonly diagnosed cancer in women worldwide. Approximately one-tenth of all patients with advanced breast cancer develop brain metastases resulting in an overall survival rate of fewer than 2 years. The challenges lie in developing new approaches to treat, monitor, and prevent breast cancer brain metastasis (BCBM). This review will provide an overview of BCBM from the integrated perspective of clinicians, researchers, and patient advocates. We will summarize the current management of BCBM, including diagnosis, treatment, and monitoring. We will highlight ongoing translational research for BCBM, including clinical trials and improved detection methods that can become the mainstay for BCBM treatment if they demonstrate efficacy. We will discuss preclinical BCBM research that focuses on the intrinsic properties of breast cancer cells and the influence of the brain microenvironment. Finally, we will spotlight emerging studies and future research needs to improve survival outcomes and preserve the quality of life for patients with BCBM. |
| first_indexed | 2024-03-11T14:09:34Z |
| format | Article |
| id | doaj.art-d0a11b6843be427c9edb69242b62887d |
| institution | Directory Open Access Journal |
| issn | 2374-4677 |
| language | English |
| last_indexed | 2024-03-11T14:09:34Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj.art-d0a11b6843be427c9edb69242b62887d2023-11-02T00:43:14ZengNature Portfolionpj Breast Cancer2374-46772021-09-017111010.1038/s41523-021-00326-5A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastasesNatalie S. Joe0Christine Hodgdon1Lianne KraemerKristin J. Redmond2Vered Stearns3Daniele M. Gilkes4Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of MedicineINSPIRE (Influencing Science through Patient-Informed Research & Education) Advocacy Program, The Johns Hopkins University School of MedicineDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of MedicineDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of MedicineDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of MedicineAbstract Breast cancer is the most commonly diagnosed cancer in women worldwide. Approximately one-tenth of all patients with advanced breast cancer develop brain metastases resulting in an overall survival rate of fewer than 2 years. The challenges lie in developing new approaches to treat, monitor, and prevent breast cancer brain metastasis (BCBM). This review will provide an overview of BCBM from the integrated perspective of clinicians, researchers, and patient advocates. We will summarize the current management of BCBM, including diagnosis, treatment, and monitoring. We will highlight ongoing translational research for BCBM, including clinical trials and improved detection methods that can become the mainstay for BCBM treatment if they demonstrate efficacy. We will discuss preclinical BCBM research that focuses on the intrinsic properties of breast cancer cells and the influence of the brain microenvironment. Finally, we will spotlight emerging studies and future research needs to improve survival outcomes and preserve the quality of life for patients with BCBM.https://doi.org/10.1038/s41523-021-00326-5 |
| spellingShingle | Natalie S. Joe Christine Hodgdon Lianne Kraemer Kristin J. Redmond Vered Stearns Daniele M. Gilkes A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases npj Breast Cancer |
| title | A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases |
| title_full | A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases |
| title_fullStr | A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases |
| title_full_unstemmed | A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases |
| title_short | A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases |
| title_sort | common goal to care cancer advocates researchers and clinicians explore current treatments and clinical trials for breast cancer brain metastases |
| url | https://doi.org/10.1038/s41523-021-00326-5 |
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