The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis

The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis

Abstract Background Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well elucidated. Methods We have developed a mouse model simulating clinical ster...

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Bibliographic Details
Main Authors: Seulgi Jeon, Hee Jin, Jin-Mo Kim, Youmin Hur, Eun Joo Song, Yoon-Jin Lee, Younghwa Na, Jaeho Cho, Yun-Sil Lee
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Biomedical Science
Subjects:
HSP27
Phosphorylation
miRNA
Pulmonary fibrosis
Smurf2
Protein degradation
Online Access:https://doi.org/10.1186/s12929-023-00896-5

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