The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review
Background: Over recent decades, a growing body of evidence has emerged linking the composition of the gut microbiota to sleep regulation. Interestingly, the prevalence of sleep disorders is commonly related to cardiometabolic comorbidities such as diabetes, impaired lipid metabolism, and metabolic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/3/390 |
| _version_ | 1797318392478171136 |
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| author | Adriano dos Santos Serena Galiè |
| author_facet | Adriano dos Santos Serena Galiè |
| author_sort | Adriano dos Santos |
| collection | DOAJ |
| description | Background: Over recent decades, a growing body of evidence has emerged linking the composition of the gut microbiota to sleep regulation. Interestingly, the prevalence of sleep disorders is commonly related to cardiometabolic comorbidities such as diabetes, impaired lipid metabolism, and metabolic syndrome (MetS). In this complex scenario, the role of the gut–brain axis as the main communicating pathway between gut microbiota and sleep regulation pathways in the brain reveals some common host–microbial biomarkers in both sleep disturbances and MetS. As the biological mechanisms behind this complex interacting network of neuroendocrine, immune, and metabolic pathways are not fully understood yet, the present systematic review aims to describe common microbial features between these two unrelated chronic conditions. Results: This systematic review highlights a total of 36 articles associating the gut microbial signature with MetS or sleep disorders. Specific emphasis is given to studies evaluating the effect of dietary patterns, dietary supplementation, and probiotics on MetS or sleep disturbances. Conclusions: Dietary choices promote microbial composition and metabolites, causing both the amelioration and impairment of MetS and sleep homeostasis. |
| first_indexed | 2024-03-08T03:52:09Z |
| format | Article |
| id | doaj.art-d0a437d11b194541b1a1878d473da791 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T03:52:09Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d0a437d11b194541b1a1878d473da7912024-02-09T15:19:48ZengMDPI AGNutrients2072-66432024-01-0116339010.3390/nu16030390The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic ReviewAdriano dos Santos0Serena Galiè1Integrative Medicine Nutrition Department, ADS Vitality B.V., 2517 AS The Hague, The NetherlandsDepartment of Experimental Oncology, European Institute of Oncology IRCCS, 20139 Milano, ItalyBackground: Over recent decades, a growing body of evidence has emerged linking the composition of the gut microbiota to sleep regulation. Interestingly, the prevalence of sleep disorders is commonly related to cardiometabolic comorbidities such as diabetes, impaired lipid metabolism, and metabolic syndrome (MetS). In this complex scenario, the role of the gut–brain axis as the main communicating pathway between gut microbiota and sleep regulation pathways in the brain reveals some common host–microbial biomarkers in both sleep disturbances and MetS. As the biological mechanisms behind this complex interacting network of neuroendocrine, immune, and metabolic pathways are not fully understood yet, the present systematic review aims to describe common microbial features between these two unrelated chronic conditions. Results: This systematic review highlights a total of 36 articles associating the gut microbial signature with MetS or sleep disorders. Specific emphasis is given to studies evaluating the effect of dietary patterns, dietary supplementation, and probiotics on MetS or sleep disturbances. Conclusions: Dietary choices promote microbial composition and metabolites, causing both the amelioration and impairment of MetS and sleep homeostasis.https://www.mdpi.com/2072-6643/16/3/390dysbiosisgut microbiomemicrobiome metabolitesmetabolic syndromesleep qualitysleep efficiency |
| spellingShingle | Adriano dos Santos Serena Galiè The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review Nutrients dysbiosis gut microbiome microbiome metabolites metabolic syndrome sleep quality sleep efficiency |
| title | The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review |
| title_full | The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review |
| title_fullStr | The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review |
| title_full_unstemmed | The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review |
| title_short | The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review |
| title_sort | microbiota gut brain axis in metabolic syndrome and sleep disorders a systematic review |
| topic | dysbiosis gut microbiome microbiome metabolites metabolic syndrome sleep quality sleep efficiency |
| url | https://www.mdpi.com/2072-6643/16/3/390 |
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