Case report and literature review: Isolated HCC- recurrence in gallbladder after curative resection
BackgroundLiver resection (LR) is considered the mainstay treatment for eligible patients with hepatocellular carcinoma (HCC) and provides a 5-year overall survival (OS) of 60%–80%. However, the recurrence rate within five years after LR remains high, ranging from 40% to 70%. Recurrence in gallbladd...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1115181/full |
| _version_ | 1827958920241479680 |
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| author | Shi-Ran Zhang Yu Ma Bo Zhou Guang-Yao Li Ping Chen Geng Chen |
| author_facet | Shi-Ran Zhang Yu Ma Bo Zhou Guang-Yao Li Ping Chen Geng Chen |
| author_sort | Shi-Ran Zhang |
| collection | DOAJ |
| description | BackgroundLiver resection (LR) is considered the mainstay treatment for eligible patients with hepatocellular carcinoma (HCC) and provides a 5-year overall survival (OS) of 60%–80%. However, the recurrence rate within five years after LR remains high, ranging from 40% to 70%. Recurrence in gallbladder after liver resection is extremely rare. Here, we present a case of isolated recurrence in gallbladder after curative resection of HCC and review the relevant literature. No similar cases have been reported before.Case presentationA 55-year-old male patient was diagnosed with HCC in 2009 and subsequently underwent a right posterior sectionectomy of the liver. In 2015, the patient underwent liver tumor radiofrequency ablation and three transarterial chemoembolization (TACE) procedures in succession for HCC recurrence. In 2019, a gallbladder lesion was detected by computed tomography (CT) without perceivable intrahepatic focus. We performed an en bloc resection of the gallbladder and hepatic segment IVb. The pathological biopsy suggested that the gallbladder tumor was moderately differentiated HCC. The patient survived more than 3 years in good condition, and there were no signs of tumor recurrence.ConclusionsIn patients with isolated gallbladder metastasis, if the lesion can be resected en bloc without remnants, surgery should be the preferred option. Both postoperative molecularly targeted drugs and immunotherapy are expected to improve the long-term prognosis. |
| first_indexed | 2024-04-09T15:43:31Z |
| format | Article |
| id | doaj.art-d0a4a51e81c74b8a8e67026a910da20d |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-09T15:43:31Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-d0a4a51e81c74b8a8e67026a910da20d2023-04-27T05:35:30ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-04-011010.3389/fsurg.2023.11151811115181Case report and literature review: Isolated HCC- recurrence in gallbladder after curative resectionShi-Ran ZhangYu MaBo ZhouGuang-Yao LiPing ChenGeng ChenBackgroundLiver resection (LR) is considered the mainstay treatment for eligible patients with hepatocellular carcinoma (HCC) and provides a 5-year overall survival (OS) of 60%–80%. However, the recurrence rate within five years after LR remains high, ranging from 40% to 70%. Recurrence in gallbladder after liver resection is extremely rare. Here, we present a case of isolated recurrence in gallbladder after curative resection of HCC and review the relevant literature. No similar cases have been reported before.Case presentationA 55-year-old male patient was diagnosed with HCC in 2009 and subsequently underwent a right posterior sectionectomy of the liver. In 2015, the patient underwent liver tumor radiofrequency ablation and three transarterial chemoembolization (TACE) procedures in succession for HCC recurrence. In 2019, a gallbladder lesion was detected by computed tomography (CT) without perceivable intrahepatic focus. We performed an en bloc resection of the gallbladder and hepatic segment IVb. The pathological biopsy suggested that the gallbladder tumor was moderately differentiated HCC. The patient survived more than 3 years in good condition, and there were no signs of tumor recurrence.ConclusionsIn patients with isolated gallbladder metastasis, if the lesion can be resected en bloc without remnants, surgery should be the preferred option. Both postoperative molecularly targeted drugs and immunotherapy are expected to improve the long-term prognosis.https://www.frontiersin.org/articles/10.3389/fsurg.2023.1115181/fullliver resectionhepatocellular carcinoma (HCC)recurrencegallbladder (GB) massmetastasis |
| spellingShingle | Shi-Ran Zhang Yu Ma Bo Zhou Guang-Yao Li Ping Chen Geng Chen Case report and literature review: Isolated HCC- recurrence in gallbladder after curative resection Frontiers in Surgery liver resection hepatocellular carcinoma (HCC) recurrence gallbladder (GB) mass metastasis |
| title | Case report and literature review: Isolated HCC- recurrence in gallbladder after curative resection |
| title_full | Case report and literature review: Isolated HCC- recurrence in gallbladder after curative resection |
| title_fullStr | Case report and literature review: Isolated HCC- recurrence in gallbladder after curative resection |
| title_full_unstemmed | Case report and literature review: Isolated HCC- recurrence in gallbladder after curative resection |
| title_short | Case report and literature review: Isolated HCC- recurrence in gallbladder after curative resection |
| title_sort | case report and literature review isolated hcc recurrence in gallbladder after curative resection |
| topic | liver resection hepatocellular carcinoma (HCC) recurrence gallbladder (GB) mass metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1115181/full |
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