Synovial calprotectin for the diagnosis of periprosthetic joint infection: a diagnostic meta-analysis
Abstract Background Periprosthetic joint infections (PJI) are a rare but severe complication of total joint arthroplasty (TJA). However, the diagnosis of PJI remains difficult. It is one of the research that focuses about diagnosis for PJI for majority researchers to discover a novel biomarker. This...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-021-02746-2 |
| _version_ | 1828155098042204160 |
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| author | Xinyu Peng Haitao Zhang Pengfei Xin Guowen Bai Yingjie Ge Miaoxin Cai Rui Wang Yueguang Fan Zhihui Pang |
| author_facet | Xinyu Peng Haitao Zhang Pengfei Xin Guowen Bai Yingjie Ge Miaoxin Cai Rui Wang Yueguang Fan Zhihui Pang |
| author_sort | Xinyu Peng |
| collection | DOAJ |
| description | Abstract Background Periprosthetic joint infections (PJI) are a rare but severe complication of total joint arthroplasty (TJA). However, the diagnosis of PJI remains difficult. It is one of the research that focuses about diagnosis for PJI for majority researchers to discover a novel biomarker. This meta-analysis tried to evaluate diagnostic value of synovial calprotectin for PJI. Methods This meta-analysis search of the literature was conducted in PubMed, EMBASE, Web of Science, and the Cochrane Library. Literature quality was appraised using Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) based on RevMan (version 5.3). The diagnostic value of calprotectin for PJI was evaluated by calculating sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), diagnostic score and area under SROC (AUC) based on the Stata version 14.0 software. We conduct subgroup analysis according to the study design, cutoff values, the country of study, and gold standard. Results Seven studies were included in this meta-analysis. The pooled sensitivity of synovial calprotectin for the diagnosis of PJI was 0.94 (95% CI, 0.87–0.98), and the specificity was 0.93 (95% CI, 0.87–0.96). The pooled AUC, PLR, and NLR for synovial calprotectin were 0.98 (95% CI, 0.96–0.99), 13.65 (95% CI, 6.89–27.07), and 0.06 (95% CI, 0.02–0.15), respectively. The pooled diagnostic score and DOR were 5.4 (95% CI, 3.96–6.85) and 222.32 (95% CI, 52.52–941.12), respectively. Conclusion In summary, this meta-analysis indicates that synovial calprotectin is a promising biomarker of assistant diagnosis for PJI, as well as recommended test for excluding diagnostic tool. |
| first_indexed | 2024-04-11T22:48:25Z |
| format | Article |
| id | doaj.art-d0a54386b62d4ac58a96383fe5f38833 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T22:48:25Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-d0a54386b62d4ac58a96383fe5f388332022-12-22T03:58:41ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2022-01-0117111210.1186/s13018-021-02746-2Synovial calprotectin for the diagnosis of periprosthetic joint infection: a diagnostic meta-analysisXinyu Peng0Haitao Zhang1Pengfei Xin2Guowen Bai3Yingjie Ge4Miaoxin Cai5Rui Wang6Yueguang Fan7Zhihui Pang8The First Clinical Medical School, Guangzhou University of Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese MedicineDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese MedicineAbstract Background Periprosthetic joint infections (PJI) are a rare but severe complication of total joint arthroplasty (TJA). However, the diagnosis of PJI remains difficult. It is one of the research that focuses about diagnosis for PJI for majority researchers to discover a novel biomarker. This meta-analysis tried to evaluate diagnostic value of synovial calprotectin for PJI. Methods This meta-analysis search of the literature was conducted in PubMed, EMBASE, Web of Science, and the Cochrane Library. Literature quality was appraised using Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) based on RevMan (version 5.3). The diagnostic value of calprotectin for PJI was evaluated by calculating sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), diagnostic score and area under SROC (AUC) based on the Stata version 14.0 software. We conduct subgroup analysis according to the study design, cutoff values, the country of study, and gold standard. Results Seven studies were included in this meta-analysis. The pooled sensitivity of synovial calprotectin for the diagnosis of PJI was 0.94 (95% CI, 0.87–0.98), and the specificity was 0.93 (95% CI, 0.87–0.96). The pooled AUC, PLR, and NLR for synovial calprotectin were 0.98 (95% CI, 0.96–0.99), 13.65 (95% CI, 6.89–27.07), and 0.06 (95% CI, 0.02–0.15), respectively. The pooled diagnostic score and DOR were 5.4 (95% CI, 3.96–6.85) and 222.32 (95% CI, 52.52–941.12), respectively. Conclusion In summary, this meta-analysis indicates that synovial calprotectin is a promising biomarker of assistant diagnosis for PJI, as well as recommended test for excluding diagnostic tool.https://doi.org/10.1186/s13018-021-02746-2Periprosthetic joint infectionCalprotectinDiagnosisMeta-analysis |
| spellingShingle | Xinyu Peng Haitao Zhang Pengfei Xin Guowen Bai Yingjie Ge Miaoxin Cai Rui Wang Yueguang Fan Zhihui Pang Synovial calprotectin for the diagnosis of periprosthetic joint infection: a diagnostic meta-analysis Journal of Orthopaedic Surgery and Research Periprosthetic joint infection Calprotectin Diagnosis Meta-analysis |
| title | Synovial calprotectin for the diagnosis of periprosthetic joint infection: a diagnostic meta-analysis |
| title_full | Synovial calprotectin for the diagnosis of periprosthetic joint infection: a diagnostic meta-analysis |
| title_fullStr | Synovial calprotectin for the diagnosis of periprosthetic joint infection: a diagnostic meta-analysis |
| title_full_unstemmed | Synovial calprotectin for the diagnosis of periprosthetic joint infection: a diagnostic meta-analysis |
| title_short | Synovial calprotectin for the diagnosis of periprosthetic joint infection: a diagnostic meta-analysis |
| title_sort | synovial calprotectin for the diagnosis of periprosthetic joint infection a diagnostic meta analysis |
| topic | Periprosthetic joint infection Calprotectin Diagnosis Meta-analysis |
| url | https://doi.org/10.1186/s13018-021-02746-2 |
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