Growth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma.

Growth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma.

Up to now, several clinical studies have been started investigating the relevance of receptor tyrosine kinase (RTK) inhibitors upon progression free survival in various pediatric brain tumors. However, single targeted kinase inhibition failed, possibly due to tumor resistance mechanisms. The present...

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Bibliographic Details
Main Authors: Mariska Sie, Wilfred F A den Dunnen, Harm Jan Lourens, Tiny G J Meeuwsen-de Boer, Frank J G Scherpen, Walderik W Zomerman, Kim R Kampen, Eelco W Hoving, Eveline S J M de Bont
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370756?pdf=render

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