Pan-cancer analysis reveals the prognostic and immunologic roles of cereblon and its significance for PROTAC design

Pan-cancer analysis reveals the prognostic and immunologic roles of cereblon and its significance for PROTAC design

Background: Cereblon (CRBN) has emerged as a vital E3 ubiquitin ligase for Proteolysis-targeting chimera (PROTAC) design. However, few studies focus on the physiological mechanism of CRBN, and more studies are needed to explore the influence of CRBN on tumorigenesis. This pan-cancer analysis aims to...

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Bibliographic Details
Main Authors: Si-Han Zhang, Na Zeng, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Meng-Yao Xu, Ye An, Xing-Yu Zhong, Si-Yang Ma, Hao-Dong He, Qi-Dong Xia, Jia Hu, Shao-Gang Wang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Cereblon
Prognosis
Pan-cancer
Immune infiltration
E3 ubiquitin ligases
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023038513

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