Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice
We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (f...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2003-04-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000400016 |
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| author | M. Rabelo E.P. Souza P.M.G. Soares A.V. Miranda F.J.A. Matos D.N. Criddle |
| author_facet | M. Rabelo E.P. Souza P.M.G. Soares A.V. Miranda F.J.A. Matos D.N. Criddle |
| author_sort | M. Rabelo |
| collection | DOAJ |
| description | We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 ± 4.4 to 40.7 ± 6.3, 36.4 ± 3.6 and 24.6 ± 3.6, respectively; N = 8-10, P<0.05) of acetic acid-induced writhing, causing up to a ~60% inhibition at the highest dose used, comparable to that obtained with indomethacin (10 mg/kg, po). At the same doses, EOOG predominantly inhibited the late (inflammatory) phase of the formalin-induced pain response (from 59.3 ± 8.3 to 40.4 ± 4.8, 23.2 ± 2.8 and 25.3 ± 5.5, respectively; N = 6, P<0.05), with a maximal reduction of ~60% of the control, although a significant reduction of the initial (neurogenic) phase was also observed at 300 mg/kg (from 62.5 ± 6.07 to 37 ± 5.9; P<0.05). On the basis of these data, we conclude that EOOG possesses interesting antinociceptive properties in the writhing and formalin tests. Due to the relatively low toxicity of EOOG, further detailed examination is strongly indicated for a better characterization of its pharmacological properties and its potential therapeutic value. |
| first_indexed | 2024-12-21T23:45:07Z |
| format | Article |
| id | doaj.art-d0af2a5ee5a24037b1bdfcb17bacb399 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-21T23:45:07Z |
| publishDate | 2003-04-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-d0af2a5ee5a24037b1bdfcb17bacb3992022-12-21T18:46:08ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2003-04-0136452152410.1590/S0100-879X2003000400016Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in miceM. RabeloE.P. SouzaP.M.G. SoaresA.V. MirandaF.J.A. MatosD.N. CriddleWe have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 ± 4.4 to 40.7 ± 6.3, 36.4 ± 3.6 and 24.6 ± 3.6, respectively; N = 8-10, P<0.05) of acetic acid-induced writhing, causing up to a ~60% inhibition at the highest dose used, comparable to that obtained with indomethacin (10 mg/kg, po). At the same doses, EOOG predominantly inhibited the late (inflammatory) phase of the formalin-induced pain response (from 59.3 ± 8.3 to 40.4 ± 4.8, 23.2 ± 2.8 and 25.3 ± 5.5, respectively; N = 6, P<0.05), with a maximal reduction of ~60% of the control, although a significant reduction of the initial (neurogenic) phase was also observed at 300 mg/kg (from 62.5 ± 6.07 to 37 ± 5.9; P<0.05). On the basis of these data, we conclude that EOOG possesses interesting antinociceptive properties in the writhing and formalin tests. Due to the relatively low toxicity of EOOG, further detailed examination is strongly indicated for a better characterization of its pharmacological properties and its potential therapeutic value.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000400016Ocimum gratissimum L.LabiataeEssential oilAntinociception |
| spellingShingle | M. Rabelo E.P. Souza P.M.G. Soares A.V. Miranda F.J.A. Matos D.N. Criddle Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice Brazilian Journal of Medical and Biological Research Ocimum gratissimum L. Labiatae Essential oil Antinociception |
| title | Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice |
| title_full | Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice |
| title_fullStr | Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice |
| title_full_unstemmed | Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice |
| title_short | Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice |
| title_sort | antinociceptive properties of the essential oil of ocimum gratissimum l labiatae in mice |
| topic | Ocimum gratissimum L. Labiatae Essential oil Antinociception |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000400016 |
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