Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding
Review presents data on medicines from the new group of cardiovascular drugs, direct oral anticoagulants (DOACs) inhibitors, as antidotes for DOAC when stopping life-threatening bleeding. DOAC therapy is accorded by hemorrhages with lower frequency than therapy by indirect anticoagulants, but really...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Столичная издательская компания
2019-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/1812 |
| _version_ | 1797232186475151360 |
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| author | A. B. Sumarokov L. I. Buryachkovskaya N. V. Lomakin |
| author_facet | A. B. Sumarokov L. I. Buryachkovskaya N. V. Lomakin |
| author_sort | A. B. Sumarokov |
| collection | DOAJ |
| description | Review presents data on medicines from the new group of cardiovascular drugs, direct oral anticoagulants (DOACs) inhibitors, as antidotes for DOAC when stopping life-threatening bleeding. DOAC therapy is accorded by hemorrhages with lower frequency than therapy by indirect anticoagulants, but really exist. New antidotes for DOACs are idarucizumab, andexanet, ciraparantag. The need in antidotes for DOAC may suddenly appear in spontaneous bleeding, during surgical operation, invasive procedure, due to trauma, in patients with stroke, kidney or liver failure. Data is given on the frequency of the main types of bleeding while taking new oral anticoagulants. Information concerning use of antidotes for DOACs in bleedings as well as use of non-specific therapy are reviewed. |
| first_indexed | 2024-03-08T14:01:28Z |
| format | Article |
| id | doaj.art-d0af3859268549e8ab4ee01121ea5501 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:56:16Z |
| publishDate | 2019-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-d0af3859268549e8ab4ee01121ea55012024-04-01T07:43:37ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532019-01-0114694495010.20996/1819-6446-2018-14-6-944-9501561Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening BleedingA. B. Sumarokov0L. I. Buryachkovskaya1N. V. Lomakin2National Medical Research Centre of CardiologyNational Medical Research Centre of CardiologyCentral Clinical Hospital of the Presidential Administration of the Russian FederationReview presents data on medicines from the new group of cardiovascular drugs, direct oral anticoagulants (DOACs) inhibitors, as antidotes for DOAC when stopping life-threatening bleeding. DOAC therapy is accorded by hemorrhages with lower frequency than therapy by indirect anticoagulants, but really exist. New antidotes for DOACs are idarucizumab, andexanet, ciraparantag. The need in antidotes for DOAC may suddenly appear in spontaneous bleeding, during surgical operation, invasive procedure, due to trauma, in patients with stroke, kidney or liver failure. Data is given on the frequency of the main types of bleeding while taking new oral anticoagulants. Information concerning use of antidotes for DOACs in bleedings as well as use of non-specific therapy are reviewed.https://www.rpcardio.online/jour/article/view/1812direct oral anticoagulantsbleedingantidotes |
| spellingShingle | A. B. Sumarokov L. I. Buryachkovskaya N. V. Lomakin Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding Рациональная фармакотерапия в кардиологии direct oral anticoagulants bleeding antidotes |
| title | Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding |
| title_full | Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding |
| title_fullStr | Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding |
| title_full_unstemmed | Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding |
| title_short | Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding |
| title_sort | specific antidotes for direct oral anticoagulants in life threatening bleeding |
| topic | direct oral anticoagulants bleeding antidotes |
| url | https://www.rpcardio.online/jour/article/view/1812 |
| work_keys_str_mv | AT absumarokov specificantidotesfordirectoralanticoagulantsinlifethreateningbleeding AT liburyachkovskaya specificantidotesfordirectoralanticoagulantsinlifethreateningbleeding AT nvlomakin specificantidotesfordirectoralanticoagulantsinlifethreateningbleeding |