Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients
Abstract A for-cause biopsy is performed to diagnose the cause of allograft dysfunction in kidney transplantation. We occasionally encounter ambiguous biopsy results in symptomatic kidney transplant recipients. Yet, the allograft survival outcome in symptomatic recipients with nonspecific allograft...
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-54596-7 |
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| author | Bon Jin Koo Hyuk Huh Byung Min Ye Yunmi Kim Byung Hyun Choi Hyun Jeong Lee Mi Seon Kang Dong Won Lee Soo Bong Lee Yeong Hoon Kim Il Young Kim Taehee Kim Seo Rin Kim |
| author_facet | Bon Jin Koo Hyuk Huh Byung Min Ye Yunmi Kim Byung Hyun Choi Hyun Jeong Lee Mi Seon Kang Dong Won Lee Soo Bong Lee Yeong Hoon Kim Il Young Kim Taehee Kim Seo Rin Kim |
| author_sort | Bon Jin Koo |
| collection | DOAJ |
| description | Abstract A for-cause biopsy is performed to diagnose the cause of allograft dysfunction in kidney transplantation. We occasionally encounter ambiguous biopsy results in symptomatic kidney transplant recipients. Yet, the allograft survival outcome in symptomatic recipients with nonspecific allograft biopsy findings remains unclear. The purpose of this study was to analyze the impact of nonspecific for-cause biopsy findings in symptomatic kidney transplant recipients. We retrospectively collected records from 773 kidney transplant recipients between January 2008 and October 2021. The characteristics of transplant recipients with nonspecific findings in the first for-cause biopsy were analyzed. Nonspecific allograft biopsy findings were defined as other biopsy findings excluding rejection, borderline rejection, calcineurin inhibitor toxicity, infection, glomerulonephritis, and diabetic nephropathy. The graft outcome was compared between recipients who had never undergone a for-cause biopsy and those who had a first for-cause biopsy with nonspecific findings. The graft survival in recipients with nonspecific for-cause biopsy findings was comparable to that in recipients who did not require the for-cause biopsy before and after propensity score matching. Even in symptomatic kidney transplant recipients, nonspecific allograft biopsy findings might not be a poor prognostic factor for allograft survival compared to recipients who did not require the for-cause biopsy. |
| first_indexed | 2024-03-07T15:11:28Z |
| format | Article |
| id | doaj.art-d0afaf4f1b104977b34958fabc15bd2b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:11:28Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-d0afaf4f1b104977b34958fabc15bd2b2024-03-05T18:38:59ZengNature PortfolioScientific Reports2045-23222024-02-011411710.1038/s41598-024-54596-7Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipientsBon Jin Koo0Hyuk Huh1Byung Min Ye2Yunmi Kim3Byung Hyun Choi4Hyun Jeong Lee5Mi Seon Kang6Dong Won Lee7Soo Bong Lee8Yeong Hoon Kim9Il Young Kim10Taehee Kim11Seo Rin Kim12Division of Nephrology, Department of Internal Medicine, Pusan National University School of MedicineDepartment of Internal Medicine-Nephrology, Inje University Busan Paik HospitalDivision of Nephrology, Department of Internal Medicine, Pusan National University School of MedicineDepartment of Internal Medicine-Nephrology, Inje University Busan Paik HospitalResearch Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan HospitalDepartment of Pathology, Pusan National University School of MedicineDepartment of Pathology, Inje University Busan Paik HospitalDivision of Nephrology, Department of Internal Medicine, Pusan National University School of MedicineDivision of Nephrology, Department of Internal Medicine, Pusan National University School of MedicineDepartment of Internal Medicine-Nephrology, Inje University Busan Paik HospitalDivision of Nephrology, Department of Internal Medicine, Pusan National University School of MedicineDepartment of Internal Medicine-Nephrology, Inje University Busan Paik HospitalDivision of Nephrology, Department of Internal Medicine, Pusan National University School of MedicineAbstract A for-cause biopsy is performed to diagnose the cause of allograft dysfunction in kidney transplantation. We occasionally encounter ambiguous biopsy results in symptomatic kidney transplant recipients. Yet, the allograft survival outcome in symptomatic recipients with nonspecific allograft biopsy findings remains unclear. The purpose of this study was to analyze the impact of nonspecific for-cause biopsy findings in symptomatic kidney transplant recipients. We retrospectively collected records from 773 kidney transplant recipients between January 2008 and October 2021. The characteristics of transplant recipients with nonspecific findings in the first for-cause biopsy were analyzed. Nonspecific allograft biopsy findings were defined as other biopsy findings excluding rejection, borderline rejection, calcineurin inhibitor toxicity, infection, glomerulonephritis, and diabetic nephropathy. The graft outcome was compared between recipients who had never undergone a for-cause biopsy and those who had a first for-cause biopsy with nonspecific findings. The graft survival in recipients with nonspecific for-cause biopsy findings was comparable to that in recipients who did not require the for-cause biopsy before and after propensity score matching. Even in symptomatic kidney transplant recipients, nonspecific allograft biopsy findings might not be a poor prognostic factor for allograft survival compared to recipients who did not require the for-cause biopsy.https://doi.org/10.1038/s41598-024-54596-7AllograftKidney transplantationFor-cause biopsyIndication biopsy |
| spellingShingle | Bon Jin Koo Hyuk Huh Byung Min Ye Yunmi Kim Byung Hyun Choi Hyun Jeong Lee Mi Seon Kang Dong Won Lee Soo Bong Lee Yeong Hoon Kim Il Young Kim Taehee Kim Seo Rin Kim Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients Scientific Reports Allograft Kidney transplantation For-cause biopsy Indication biopsy |
| title | Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients |
| title_full | Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients |
| title_fullStr | Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients |
| title_full_unstemmed | Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients |
| title_short | Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients |
| title_sort | impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients |
| topic | Allograft Kidney transplantation For-cause biopsy Indication biopsy |
| url | https://doi.org/10.1038/s41598-024-54596-7 |
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