In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone as Promising Cyclooxygenase Inhibitors

In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone as Promising Cyclooxygenase Inhibitors

Since long-term use of classic NSAIDs can cause severe side effects related mainly to the gastroduodenal tract, discovery of novel cyclooxygenase inhibitors with a safe gastric profile still remains a crucial challenge. Based on the most recent literature data and previous own studies, we decided to...

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Bibliographic Details
Main Authors: Krzysztof Peregrym, Łukasz Szczukowski, Benita Wiatrak, Katarzyna Potyrak, Żaneta Czyżnikowska, Piotr Świątek
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
anti-inflammatory activity
1,3,4-oxadiazole
molecular docking
double pharmacophore approach
pyridazinone
antioxidants
Online Access:https://www.mdpi.com/1422-0067/22/17/9130

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https://www.mdpi.com/1422-0067/22/17/9130

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