Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study
BackgroundAtrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. Methods and ResultsData from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used t...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-05-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.008414 |
| _version_ | 1819178549681061888 |
|---|---|
| author | Jocasta Ball Maja‐Lisa Løchen Tom Wilsgaard Henrik Schirmer Laila A. Hopstock Bente Morseth Ellisiv B. Mathiesen Inger Njølstad Sweta Tiwari Ekaterina Sharashova |
| author_facet | Jocasta Ball Maja‐Lisa Løchen Tom Wilsgaard Henrik Schirmer Laila A. Hopstock Bente Morseth Ellisiv B. Mathiesen Inger Njølstad Sweta Tiwari Ekaterina Sharashova |
| author_sort | Jocasta Ball |
| collection | DOAJ |
| description | BackgroundAtrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. Methods and ResultsData from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used. AF diagnosis was derived from record linkage and end point adjudication. Cox regression analysis was conducted using fractional polynomials of BMI and BMI change with models adjusted for age, baseline BMI (change analyses), risk factors, comorbidities, and antihypertensive medications.Data were available for 24 799 individuals from the fourth survey (mean age, 45.5±14.2 years; 52.9% women). Over 15.7±5.5 years, 811 women (6.2%) and 918 men (7.9%) developed AF. In men, lower BMI decreased AF risk and higher BMI increased risk (hazard ratios [95% confidence intervals] for BMI 18 or 40 kg/m2 compared with 23 kg/m2 were 0.75 [0.70–0.81] and 4.42 [3.00–6.53], respectively). The same pattern was identified in women. Two surveys were attended by 14 652 individuals. In men and women, a decrease in BMI over time was associated with decreased AF risk and an increase in BMI was associated with increased AF risk. ConclusionsWithin a population cohort, BMI was positively associated with AF risk. Change in BMI over time influenced AF risk in both men and women. |
| first_indexed | 2024-12-22T21:44:19Z |
| format | Article |
| id | doaj.art-d0b1d650d4674373a26807b5c4ef88b7 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T21:44:19Z |
| publishDate | 2018-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-d0b1d650d4674373a26807b5c4ef88b72022-12-21T18:11:31ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802018-05-017910.1161/JAHA.117.008414Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø StudyJocasta Ball0Maja‐Lisa Løchen1Tom Wilsgaard2Henrik Schirmer3Laila A. Hopstock4Bente Morseth5Ellisiv B. Mathiesen6Inger Njølstad7Sweta Tiwari8Ekaterina Sharashova9Pre‐Clinical Disease and Prevention, Baker Heart and Diabetes Institute, Melbourne, AustraliaPre‐Clinical Disease and Prevention, Baker Heart and Diabetes Institute, Melbourne, AustraliaDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, NorwayDepartment of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, NorwayDepartment of Health and Care Sciences, UiT The Arctic University of Norway, Tromsø, NorwayDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, NorwayDepartment of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, NorwayDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, NorwayDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, NorwayDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, NorwayBackgroundAtrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. Methods and ResultsData from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used. AF diagnosis was derived from record linkage and end point adjudication. Cox regression analysis was conducted using fractional polynomials of BMI and BMI change with models adjusted for age, baseline BMI (change analyses), risk factors, comorbidities, and antihypertensive medications.Data were available for 24 799 individuals from the fourth survey (mean age, 45.5±14.2 years; 52.9% women). Over 15.7±5.5 years, 811 women (6.2%) and 918 men (7.9%) developed AF. In men, lower BMI decreased AF risk and higher BMI increased risk (hazard ratios [95% confidence intervals] for BMI 18 or 40 kg/m2 compared with 23 kg/m2 were 0.75 [0.70–0.81] and 4.42 [3.00–6.53], respectively). The same pattern was identified in women. Two surveys were attended by 14 652 individuals. In men and women, a decrease in BMI over time was associated with decreased AF risk and an increase in BMI was associated with increased AF risk. ConclusionsWithin a population cohort, BMI was positively associated with AF risk. Change in BMI over time influenced AF risk in both men and women.https://www.ahajournals.org/doi/10.1161/JAHA.117.008414atrial fibrillationbody mass indexincidencesex differences |
| spellingShingle | Jocasta Ball Maja‐Lisa Løchen Tom Wilsgaard Henrik Schirmer Laila A. Hopstock Bente Morseth Ellisiv B. Mathiesen Inger Njølstad Sweta Tiwari Ekaterina Sharashova Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atrial fibrillation body mass index incidence sex differences |
| title | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
| title_full | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
| title_fullStr | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
| title_full_unstemmed | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
| title_short | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
| title_sort | sex differences in the impact of body mass index on the risk of future atrial fibrillation insights from the longitudinal population based tromso study |
| topic | atrial fibrillation body mass index incidence sex differences |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.008414 |
| work_keys_str_mv | AT jocastaball sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT majalisaløchen sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT tomwilsgaard sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT henrikschirmer sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT lailaahopstock sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT bentemorseth sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT ellisivbmathiesen sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT ingernjølstad sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT swetatiwari sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy AT ekaterinasharashova sexdifferencesintheimpactofbodymassindexontheriskoffutureatrialfibrillationinsightsfromthelongitudinalpopulationbasedtromsøstudy |