Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications
This study aimed to examine the difference in health-related quality of life (HRQOL) and diabetes-related healthcare events (HCEs) among adults with diabetes who were on metformin, sulfonylurea, insulin, or thiazolidinedione (TZD) monotherapy. The data were sourced from the Medical Expenditure Panel...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/4/541 |
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| author | Tadesse Melaku Abegaz Askal Ayalew Ali |
| author_facet | Tadesse Melaku Abegaz Askal Ayalew Ali |
| author_sort | Tadesse Melaku Abegaz |
| collection | DOAJ |
| description | This study aimed to examine the difference in health-related quality of life (HRQOL) and diabetes-related healthcare events (HCEs) among adults with diabetes who were on metformin, sulfonylurea, insulin, or thiazolidinedione (TZD) monotherapy. The data were sourced from the Medical Expenditure Panel Survey (MEPS). Diabetes patients ≥18 years old who had a complete record of physical component score and mental component scores in round 2 and round 4 of the survey were included. The primary outcome was HRQOL of diabetes patients as measured by the Medical Outcome Study short-form (SF-12v2<sup>TM</sup>). Multinomial logistic regression and negative binomial regression were conducted to determine associated factors of HRQOL and HCE, respectively. Overall, 5387 patients were included for analysis. Nearly 60% of patients had unchanged HRQOL after the follow-up, whereas almost 15% to 20% of patients showed improvement in HRQOL. The relative risk of declined mental HRQOL was 1.5 times higher relative to unchanged mental HRQOL in patients who were on sulfonylurea 1.55 [1.1–2.17, <i>p</i> = 0.01] than metformin users. The rate of HCE decreased by a factor of 0.79, [95% CI: 0.63–0.99] in patients with no history of hypertension. Patients on sulfonylurea 1.53 [1.20–1.95, <0.01], insulin 2.00 [1.55–2.70, <0.01], and TZD 1.78 [1.23–2.58, <0.01] had increased risk of HCE compared to patients who were on metformin. In general, antidiabetic medications modestly improved HRQOL in patients with diabetes during the follow-up period. Metformin had a lower rate of HCE as compared to other medications. The selection of anti-diabetes medications should focus on HRQOL in addition to controlling glucose level. |
| first_indexed | 2024-03-11T08:46:17Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T08:46:17Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-d0b32bd8922d4cbf8dd66dfa87db9e622023-11-16T20:46:40ZengMDPI AGHealthcare2227-90322023-02-0111454110.3390/healthcare11040541Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes MedicationsTadesse Melaku Abegaz0Askal Ayalew Ali1Economic, Social and Administrative Pharmacy (ESAP), College of Pharmacy and Pharmaceutical Sciences, Institute of Public Heath, Florida A&M University, Tallahassee, FL 32307, USAEconomic, Social and Administrative Pharmacy (ESAP), College of Pharmacy and Pharmaceutical Sciences, Institute of Public Heath, Florida A&M University, Tallahassee, FL 32307, USAThis study aimed to examine the difference in health-related quality of life (HRQOL) and diabetes-related healthcare events (HCEs) among adults with diabetes who were on metformin, sulfonylurea, insulin, or thiazolidinedione (TZD) monotherapy. The data were sourced from the Medical Expenditure Panel Survey (MEPS). Diabetes patients ≥18 years old who had a complete record of physical component score and mental component scores in round 2 and round 4 of the survey were included. The primary outcome was HRQOL of diabetes patients as measured by the Medical Outcome Study short-form (SF-12v2<sup>TM</sup>). Multinomial logistic regression and negative binomial regression were conducted to determine associated factors of HRQOL and HCE, respectively. Overall, 5387 patients were included for analysis. Nearly 60% of patients had unchanged HRQOL after the follow-up, whereas almost 15% to 20% of patients showed improvement in HRQOL. The relative risk of declined mental HRQOL was 1.5 times higher relative to unchanged mental HRQOL in patients who were on sulfonylurea 1.55 [1.1–2.17, <i>p</i> = 0.01] than metformin users. The rate of HCE decreased by a factor of 0.79, [95% CI: 0.63–0.99] in patients with no history of hypertension. Patients on sulfonylurea 1.53 [1.20–1.95, <0.01], insulin 2.00 [1.55–2.70, <0.01], and TZD 1.78 [1.23–2.58, <0.01] had increased risk of HCE compared to patients who were on metformin. In general, antidiabetic medications modestly improved HRQOL in patients with diabetes during the follow-up period. Metformin had a lower rate of HCE as compared to other medications. The selection of anti-diabetes medications should focus on HRQOL in addition to controlling glucose level.https://www.mdpi.com/2227-9032/11/4/541anti-diabetes medicationscomparative effectivenessdiabetesquality of life |
| spellingShingle | Tadesse Melaku Abegaz Askal Ayalew Ali Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications Healthcare anti-diabetes medications comparative effectiveness diabetes quality of life |
| title | Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications |
| title_full | Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications |
| title_fullStr | Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications |
| title_full_unstemmed | Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications |
| title_short | Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications |
| title_sort | health related quality of life and healthcare events in patients with monotherapy of anti diabetes medications |
| topic | anti-diabetes medications comparative effectiveness diabetes quality of life |
| url | https://www.mdpi.com/2227-9032/11/4/541 |
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