Prevalence of premature ovarian insufficiency and its determinants in Iranian populations: Tehran lipid and glucose study
Abstract Background Premature ovarian insufficiency (POI) considered as a concerning health issue for women of reproductive age. In this study we aim to estimate the prevalence of POI and assessing the influential factors. Methods Data was obtained from Tehran lipid and glucose study (TLGS). All eli...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-021-01228-1 |
| _version_ | 1819275895604510720 |
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| author | Marzieh Rostami Dovom Razieh Bidhendi-Yarandi Kazem Mohammad Maryam Farahmand Fereidoun Azizi Fahimeh Ramezani Tehrani |
| author_facet | Marzieh Rostami Dovom Razieh Bidhendi-Yarandi Kazem Mohammad Maryam Farahmand Fereidoun Azizi Fahimeh Ramezani Tehrani |
| author_sort | Marzieh Rostami Dovom |
| collection | DOAJ |
| description | Abstract Background Premature ovarian insufficiency (POI) considered as a concerning health issue for women of reproductive age. In this study we aim to estimate the prevalence of POI and assessing the influential factors. Methods Data was obtained from Tehran lipid and glucose study (TLGS). All eligible post-menarcheal female participants of the TLGS, ages 20–65, were recruited (n = 6521). Participants were followed for the event of menopause, and age at menopause was recorded. Kaplan Meier analysis was applied to estimate mean and median for age at menopause. Weibull accelerated failure time survival regression model (AFT), was applied to assess influential determinants of POI. Conditional probability approach was used to provide estimation for prevalence of POI. Results In this population-based study, the prevalence of POI (menopause age < 40 years) and early menopause (menopause age < 45 years) were estimated 3.5% and 24.6%, respectively. AFT model showed that in comparison to normal weight women, time to menopause was decreased by − 0.09 year (95% CI − 0.27, − 0.01, p = 0.023) and − 0.03 year (95% CI − 0.05, − 0.02, p = 0.000) in underweight and overweight women, respectively. Moreover, time to natural menopause was increased by 0.12 year (95% CI 0.07 to 0.17, p = 0.000) in women used oral contraceptives for > 6 months. Conclusion About one quartile of Iranian women experienced menopause at an age less than 45, especially the non-normal weight ones; this high prevalence is a critical public health concerns that needs to be addressed by health policy makers. |
| first_indexed | 2024-12-23T23:31:36Z |
| format | Article |
| id | doaj.art-d0b351154d1c4b5e8b2ecf1075dc0d19 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-12-23T23:31:36Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-d0b351154d1c4b5e8b2ecf1075dc0d192022-12-21T17:26:01ZengBMCBMC Women's Health1472-68742021-02-012111610.1186/s12905-021-01228-1Prevalence of premature ovarian insufficiency and its determinants in Iranian populations: Tehran lipid and glucose studyMarzieh Rostami Dovom0Razieh Bidhendi-Yarandi1Kazem Mohammad2Maryam Farahmand3Fereidoun Azizi4Fahimeh Ramezani Tehrani5Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical SciencesReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesAbstract Background Premature ovarian insufficiency (POI) considered as a concerning health issue for women of reproductive age. In this study we aim to estimate the prevalence of POI and assessing the influential factors. Methods Data was obtained from Tehran lipid and glucose study (TLGS). All eligible post-menarcheal female participants of the TLGS, ages 20–65, were recruited (n = 6521). Participants were followed for the event of menopause, and age at menopause was recorded. Kaplan Meier analysis was applied to estimate mean and median for age at menopause. Weibull accelerated failure time survival regression model (AFT), was applied to assess influential determinants of POI. Conditional probability approach was used to provide estimation for prevalence of POI. Results In this population-based study, the prevalence of POI (menopause age < 40 years) and early menopause (menopause age < 45 years) were estimated 3.5% and 24.6%, respectively. AFT model showed that in comparison to normal weight women, time to menopause was decreased by − 0.09 year (95% CI − 0.27, − 0.01, p = 0.023) and − 0.03 year (95% CI − 0.05, − 0.02, p = 0.000) in underweight and overweight women, respectively. Moreover, time to natural menopause was increased by 0.12 year (95% CI 0.07 to 0.17, p = 0.000) in women used oral contraceptives for > 6 months. Conclusion About one quartile of Iranian women experienced menopause at an age less than 45, especially the non-normal weight ones; this high prevalence is a critical public health concerns that needs to be addressed by health policy makers.https://doi.org/10.1186/s12905-021-01228-1Premature ovarian failurePremature ovarian insufficiencyPrevalenceEarly menopauseLate menopause |
| spellingShingle | Marzieh Rostami Dovom Razieh Bidhendi-Yarandi Kazem Mohammad Maryam Farahmand Fereidoun Azizi Fahimeh Ramezani Tehrani Prevalence of premature ovarian insufficiency and its determinants in Iranian populations: Tehran lipid and glucose study BMC Women's Health Premature ovarian failure Premature ovarian insufficiency Prevalence Early menopause Late menopause |
| title | Prevalence of premature ovarian insufficiency and its determinants in Iranian populations: Tehran lipid and glucose study |
| title_full | Prevalence of premature ovarian insufficiency and its determinants in Iranian populations: Tehran lipid and glucose study |
| title_fullStr | Prevalence of premature ovarian insufficiency and its determinants in Iranian populations: Tehran lipid and glucose study |
| title_full_unstemmed | Prevalence of premature ovarian insufficiency and its determinants in Iranian populations: Tehran lipid and glucose study |
| title_short | Prevalence of premature ovarian insufficiency and its determinants in Iranian populations: Tehran lipid and glucose study |
| title_sort | prevalence of premature ovarian insufficiency and its determinants in iranian populations tehran lipid and glucose study |
| topic | Premature ovarian failure Premature ovarian insufficiency Prevalence Early menopause Late menopause |
| url | https://doi.org/10.1186/s12905-021-01228-1 |
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