Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw
Background: Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect of antiresorptive therapy in the oncological setting. With growing evidence that impaired angiogenesis may represent a key factor in pathogenesis, the aim of this study was to evaluate an autologous pl...
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/3/682 |
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| author | Sebastian Blatt Maximilian Krüger Peer W. Kämmerer Daniel G. E. Thiem Philipp Matheis Anne-Katrin Eisenbeiß Jörg Wiltfang Bilal Al-Nawas Hendrik Naujokat |
| author_facet | Sebastian Blatt Maximilian Krüger Peer W. Kämmerer Daniel G. E. Thiem Philipp Matheis Anne-Katrin Eisenbeiß Jörg Wiltfang Bilal Al-Nawas Hendrik Naujokat |
| author_sort | Sebastian Blatt |
| collection | DOAJ |
| description | Background: Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect of antiresorptive therapy in the oncological setting. With growing evidence that impaired angiogenesis may represent a key factor in pathogenesis, the aim of this study was to evaluate an autologous platelet concentrate as a possible additive in surgical therapy to optimize vascularization and, subsequently, resolution rates. Material and Methods: A non-interventional, prospective, multicenter study was conducted, and all patients with stage I-III MRONJ, undergoing antiresorptive therapy for an oncological indication, were included. The necrosis was treated surgically without (study arm A) or with (arm B) the addition of an autologous platelet concentrate (platelet-rich fibrin, PRF). Results: After 5, 14, and 42 days postoperative, wound healing (primary outcome: mucosal integrity) as well as downstaging, pain perception, and oral health-related quality of life (secondary outcome) were assessed via clinical evaluation. Among the 52 patients included, primarily with MRONJ stage I and II, the use of PRF as an additive in surgical therapy did not display a significant advantage for wound healing (<i>p</i> = 0.302), downstaging (<i>p</i> = 0.9), pain reduction (<i>p</i> = 0.169), or quality of life (<i>p</i> = 0.9). Summary: In conclusion, PRF as an adjunct did not significantly optimize wound healing. Further, no significant changes in terms of downstaging, pain sensation, and oral health-related quality of life were found. |
| first_indexed | 2024-03-09T23:41:17Z |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:41:17Z |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-d0b71bd3b70d4e6eacb1c1f0d39b742b2023-11-23T16:52:21ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111368210.3390/jcm11030682Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the JawSebastian Blatt0Maximilian Krüger1Peer W. Kämmerer2Daniel G. E. Thiem3Philipp Matheis4Anne-Katrin Eisenbeiß5Jörg Wiltfang6Bilal Al-Nawas7Hendrik Naujokat8Department of Oral and Maxillofacial Surgery, University Medical Center, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Medical Center, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Medical Center, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Medical Center, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Medical Center, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Hospital Schleswig-Holstein, Christian-Albrechts-University, 24118 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, University Hospital Schleswig-Holstein, Christian-Albrechts-University, 24118 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, University Medical Center, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Hospital Schleswig-Holstein, Christian-Albrechts-University, 24118 Kiel, GermanyBackground: Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect of antiresorptive therapy in the oncological setting. With growing evidence that impaired angiogenesis may represent a key factor in pathogenesis, the aim of this study was to evaluate an autologous platelet concentrate as a possible additive in surgical therapy to optimize vascularization and, subsequently, resolution rates. Material and Methods: A non-interventional, prospective, multicenter study was conducted, and all patients with stage I-III MRONJ, undergoing antiresorptive therapy for an oncological indication, were included. The necrosis was treated surgically without (study arm A) or with (arm B) the addition of an autologous platelet concentrate (platelet-rich fibrin, PRF). Results: After 5, 14, and 42 days postoperative, wound healing (primary outcome: mucosal integrity) as well as downstaging, pain perception, and oral health-related quality of life (secondary outcome) were assessed via clinical evaluation. Among the 52 patients included, primarily with MRONJ stage I and II, the use of PRF as an additive in surgical therapy did not display a significant advantage for wound healing (<i>p</i> = 0.302), downstaging (<i>p</i> = 0.9), pain reduction (<i>p</i> = 0.169), or quality of life (<i>p</i> = 0.9). Summary: In conclusion, PRF as an adjunct did not significantly optimize wound healing. Further, no significant changes in terms of downstaging, pain sensation, and oral health-related quality of life were found.https://www.mdpi.com/2077-0383/11/3/682MRONJplatelet rich fibrinangiogenesis |
| spellingShingle | Sebastian Blatt Maximilian Krüger Peer W. Kämmerer Daniel G. E. Thiem Philipp Matheis Anne-Katrin Eisenbeiß Jörg Wiltfang Bilal Al-Nawas Hendrik Naujokat Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw Journal of Clinical Medicine MRONJ platelet rich fibrin angiogenesis |
| title | Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw |
| title_full | Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw |
| title_fullStr | Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw |
| title_full_unstemmed | Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw |
| title_short | Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw |
| title_sort | non interventional prospective observational study of platelet rich fibrin as a therapy adjunctive in patients with medication related osteonecrosis of the jaw |
| topic | MRONJ platelet rich fibrin angiogenesis |
| url | https://www.mdpi.com/2077-0383/11/3/682 |
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