Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) Study
(1) Background: Glioma is the most common primary tumor in the central nervous system, and glioma-related epilepsy (GRE) is one of its common symptoms. The abnormalities of white matter fiber tracts are involved in attributing changes in patients with epilepsy (Rudà, R, 2012).This study aimed to ass...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/12/9/1169 |
| _version_ | 1797490563635740672 |
|---|---|
| author | Hong Zhang Chunyao Zhou Qiang Zhu Tianshi Li Yinyan Wang Lei Wang |
| author_facet | Hong Zhang Chunyao Zhou Qiang Zhu Tianshi Li Yinyan Wang Lei Wang |
| author_sort | Hong Zhang |
| collection | DOAJ |
| description | (1) Background: Glioma is the most common primary tumor in the central nervous system, and glioma-related epilepsy (GRE) is one of its common symptoms. The abnormalities of white matter fiber tracts are involved in attributing changes in patients with epilepsy (Rudà, R, 2012).This study aimed to assess frontal lobe gliomas’ effects on the cerebral white matter fiber tracts. (2) Methods: Thirty patients with frontal lobe glioma were enrolled and divided into two groups (Ep and nEep). Among them, five patients were excluded due to apparent insular or temporal involvement. A set of 14 age and gender-matched healthy controls were also included. All the enrolled subjects underwent preoperative conventional magnetic resonance images (MRI) and diffusion tensor imaging (DTI). Furthermore, we used tract-based spatial statistics to analyze the characteristics of the white matter fiber tracts. (3) Results: The two patient groups showed similar patterns of mean diffusivity (MD) elevations in most regions; however, in the ipsilateral inferior fronto-occipital fasciculus (IFOF), superior longitudinal fasciculus (SLF), and superior corona radiata, the significant voxels of the EP group were more apparent than in the nEP group. No significant fractional anisotropy (FA) elevations or MD degenerations were found in the current study. (4) Conclusions: Gliomas grow and invade along white matter fiber tracts. This study assessed the effects of GRE on the white matter fiber bundle skeleton by TBSS, and we found that the changes in the white matter skeleton of the frontal lobe tumor-related epilepsy were mainly concentrated in the IFOF, SLF, and superior corona radiata. This reveals that GRE significantly affects the white matter fiber microstructure of the tumor. |
| first_indexed | 2024-03-10T00:34:47Z |
| format | Article |
| id | doaj.art-d0b85ae20fc64c3098f197fbf290010f |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T00:34:47Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d0b85ae20fc64c3098f197fbf290010f2023-11-23T15:20:21ZengMDPI AGBrain Sciences2076-34252022-08-01129116910.3390/brainsci12091169Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) StudyHong Zhang0Chunyao Zhou1Qiang Zhu2Tianshi Li3Yinyan Wang4Lei Wang5Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China(1) Background: Glioma is the most common primary tumor in the central nervous system, and glioma-related epilepsy (GRE) is one of its common symptoms. The abnormalities of white matter fiber tracts are involved in attributing changes in patients with epilepsy (Rudà, R, 2012).This study aimed to assess frontal lobe gliomas’ effects on the cerebral white matter fiber tracts. (2) Methods: Thirty patients with frontal lobe glioma were enrolled and divided into two groups (Ep and nEep). Among them, five patients were excluded due to apparent insular or temporal involvement. A set of 14 age and gender-matched healthy controls were also included. All the enrolled subjects underwent preoperative conventional magnetic resonance images (MRI) and diffusion tensor imaging (DTI). Furthermore, we used tract-based spatial statistics to analyze the characteristics of the white matter fiber tracts. (3) Results: The two patient groups showed similar patterns of mean diffusivity (MD) elevations in most regions; however, in the ipsilateral inferior fronto-occipital fasciculus (IFOF), superior longitudinal fasciculus (SLF), and superior corona radiata, the significant voxels of the EP group were more apparent than in the nEP group. No significant fractional anisotropy (FA) elevations or MD degenerations were found in the current study. (4) Conclusions: Gliomas grow and invade along white matter fiber tracts. This study assessed the effects of GRE on the white matter fiber bundle skeleton by TBSS, and we found that the changes in the white matter skeleton of the frontal lobe tumor-related epilepsy were mainly concentrated in the IFOF, SLF, and superior corona radiata. This reveals that GRE significantly affects the white matter fiber microstructure of the tumor.https://www.mdpi.com/2076-3425/12/9/1169glioma-related epilepsydiffusion tensor imagingtract-based spatial statistical |
| spellingShingle | Hong Zhang Chunyao Zhou Qiang Zhu Tianshi Li Yinyan Wang Lei Wang Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) Study Brain Sciences glioma-related epilepsy diffusion tensor imaging tract-based spatial statistical |
| title | Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) Study |
| title_full | Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) Study |
| title_fullStr | Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) Study |
| title_full_unstemmed | Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) Study |
| title_short | Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) Study |
| title_sort | characteristics of microstructural changes associated with glioma related epilepsy a diffusion tensor imaging dti study |
| topic | glioma-related epilepsy diffusion tensor imaging tract-based spatial statistical |
| url | https://www.mdpi.com/2076-3425/12/9/1169 |
| work_keys_str_mv | AT hongzhang characteristicsofmicrostructuralchangesassociatedwithgliomarelatedepilepsyadiffusiontensorimagingdtistudy AT chunyaozhou characteristicsofmicrostructuralchangesassociatedwithgliomarelatedepilepsyadiffusiontensorimagingdtistudy AT qiangzhu characteristicsofmicrostructuralchangesassociatedwithgliomarelatedepilepsyadiffusiontensorimagingdtistudy AT tianshili characteristicsofmicrostructuralchangesassociatedwithgliomarelatedepilepsyadiffusiontensorimagingdtistudy AT yinyanwang characteristicsofmicrostructuralchangesassociatedwithgliomarelatedepilepsyadiffusiontensorimagingdtistudy AT leiwang characteristicsofmicrostructuralchangesassociatedwithgliomarelatedepilepsyadiffusiontensorimagingdtistudy |