Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment
After stroke, dynamic changes take place from necrotic-apoptotic continuum, inflammatory response to poststroke neurogenesis, and remodeling of the network. These changes and baseline brain pathology such as small vessel disease (SVD) and amyloid burden may be associated with the occurrence of early...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/7/773 |
| _version_ | 1827687897496551424 |
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| author | Kang-Po Lee Alice Y. W. Chang Pi-Shan Sung |
| author_facet | Kang-Po Lee Alice Y. W. Chang Pi-Shan Sung |
| author_sort | Kang-Po Lee |
| collection | DOAJ |
| description | After stroke, dynamic changes take place from necrotic-apoptotic continuum, inflammatory response to poststroke neurogenesis, and remodeling of the network. These changes and baseline brain pathology such as small vessel disease (SVD) and amyloid burden may be associated with the occurrence of early or late poststroke cognitive impairment (PSCI) or dementia (PSD), which affect not only stroke victims but also their families and even society. We reviewed the current concepts and understanding of the pathophysiology for PSCI/PSD and identified useful tools for the diagnosis and the prediction of PSCI in serological, CSF, and image characteristics. Then, we untangled their relationships with blood pressure (BP) and blood pressure variability (BPV), important but often overlooked risk factors for PSCI/PSD. Finally, we provided evidence for the modifying effects of BP and BPV on PSCI as well as pharmacological and non-pharmacological interventions and life style modification for PSCI/PSD prevention and treatment. |
| first_indexed | 2024-03-10T09:45:25Z |
| format | Article |
| id | doaj.art-d0b86ef586634e5db3d6b1046ccef0cb |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T09:45:25Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d0b86ef586634e5db3d6b1046ccef0cb2023-11-22T03:16:46ZengMDPI AGBiomedicines2227-90592021-07-019777310.3390/biomedicines9070773Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive ImpairmentKang-Po Lee0Alice Y. W. Chang1Pi-Shan Sung2Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanAfter stroke, dynamic changes take place from necrotic-apoptotic continuum, inflammatory response to poststroke neurogenesis, and remodeling of the network. These changes and baseline brain pathology such as small vessel disease (SVD) and amyloid burden may be associated with the occurrence of early or late poststroke cognitive impairment (PSCI) or dementia (PSD), which affect not only stroke victims but also their families and even society. We reviewed the current concepts and understanding of the pathophysiology for PSCI/PSD and identified useful tools for the diagnosis and the prediction of PSCI in serological, CSF, and image characteristics. Then, we untangled their relationships with blood pressure (BP) and blood pressure variability (BPV), important but often overlooked risk factors for PSCI/PSD. Finally, we provided evidence for the modifying effects of BP and BPV on PSCI as well as pharmacological and non-pharmacological interventions and life style modification for PSCI/PSD prevention and treatment.https://www.mdpi.com/2227-9059/9/7/773post-stroke cognitive impairmentdementiastrokepathophysiologytreatmentsblood pressure |
| spellingShingle | Kang-Po Lee Alice Y. W. Chang Pi-Shan Sung Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment Biomedicines post-stroke cognitive impairment dementia stroke pathophysiology treatments blood pressure |
| title | Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment |
| title_full | Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment |
| title_fullStr | Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment |
| title_full_unstemmed | Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment |
| title_short | Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment |
| title_sort | association between blood pressure blood pressure variability and post stroke cognitive impairment |
| topic | post-stroke cognitive impairment dementia stroke pathophysiology treatments blood pressure |
| url | https://www.mdpi.com/2227-9059/9/7/773 |
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