Anatomic characteristics and novel transplantation model of the canine uterus
Background : In Vietnam, the rate of absolute uterine factor infertility is increasing, but no study has been published on uterine transplantation. The present study was designed to comprehensively observe the canine uterine anatomy and to examine the possibility of using a living canine donor for u...
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| Format: | Article |
| Language: | English |
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Korean Society for Transplantation
2023-06-01
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| Series: | Korean Journal of Transplantation |
| Subjects: | |
| Online Access: | http://www.ekjt.org/journal/view.html?doi=10.4285/kjt.23.0019 |
| _version_ | 1827360654440267776 |
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| author | Xuan-Hai Do Thanh-Hai Tong Trung-Chuc Nguyen Tuan-Anh Ngo Minh-Trang Thi Tran |
| author_facet | Xuan-Hai Do Thanh-Hai Tong Trung-Chuc Nguyen Tuan-Anh Ngo Minh-Trang Thi Tran |
| author_sort | Xuan-Hai Do |
| collection | DOAJ |
| description | Background : In Vietnam, the rate of absolute uterine factor infertility is increasing, but no study has been published on uterine transplantation. The present study was designed to comprehensively observe the canine uterine anatomy and to examine the possibility of using a living canine donor for uterine transplantation training and further research. Methods : Ten female Vietnamese mixed-breed dogs were sacrificed for anatomical research, and 15 additional pairs were used to evaluate the novel uterine transplant model. Results : The anatomic features of the canine uterus differed considerably from those of the human uterus, with the uterine vessels originating from branches of the pudendal vessels (also known as the vaginal vessels). The uterine vascular pedicle had a small diameter (1 to 1.5 mm for arteries and 1.2 to 2.0 mm for veins) and required manipulation under a microscope. To perform uterine transplantation, the donor specimen’s artery and vein lengths were successfully reconstructed by anastomosis between both sides of the vasculature using autologous Y-shaped subcutaneous veins. The living-donor uterine transplantation model constructed in this study was feasible, with the transplanted uterus surviving in 86.7% of cases (13/15). Conclusions: Uterine transplantation was successfully performed in a Vietnamese canine living donor model. This model could be helpful in uterine transplantation training and improve the transplantation success rate in humans. |
| first_indexed | 2024-03-08T06:51:27Z |
| format | Article |
| id | doaj.art-d0bbf5fa7b224872a304d1f3855feeba |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T06:51:27Z |
| publishDate | 2023-06-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-d0bbf5fa7b224872a304d1f3855feeba2024-02-03T06:51:12ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902023-06-0137210911710.4285/kjt.23.0019kjt.23.0019Anatomic characteristics and novel transplantation model of the canine uterusXuan-Hai Do0Thanh-Hai Tong1Trung-Chuc Nguyen2Tuan-Anh Ngo3Minh-Trang Thi Tran4Department of Practical and Experimental Surgery, Vietnam Military Medical University, Hanoi, VietnamPlastic Surgery Center, National Burn Hospital, Vietnam Military Medical University, Hanoi, VietnamDepartment of Practical and Experimental Surgery, Vietnam Military Medical University, Hanoi, VietnamDepartment of Cardiovascular Surgery, 108 Military Central Hospital, Hanoi, VietnamDepartment of Obstetrics, 108 Military Central Hospital, Hanoi, VietnamBackground : In Vietnam, the rate of absolute uterine factor infertility is increasing, but no study has been published on uterine transplantation. The present study was designed to comprehensively observe the canine uterine anatomy and to examine the possibility of using a living canine donor for uterine transplantation training and further research. Methods : Ten female Vietnamese mixed-breed dogs were sacrificed for anatomical research, and 15 additional pairs were used to evaluate the novel uterine transplant model. Results : The anatomic features of the canine uterus differed considerably from those of the human uterus, with the uterine vessels originating from branches of the pudendal vessels (also known as the vaginal vessels). The uterine vascular pedicle had a small diameter (1 to 1.5 mm for arteries and 1.2 to 2.0 mm for veins) and required manipulation under a microscope. To perform uterine transplantation, the donor specimen’s artery and vein lengths were successfully reconstructed by anastomosis between both sides of the vasculature using autologous Y-shaped subcutaneous veins. The living-donor uterine transplantation model constructed in this study was feasible, with the transplanted uterus surviving in 86.7% of cases (13/15). Conclusions: Uterine transplantation was successfully performed in a Vietnamese canine living donor model. This model could be helpful in uterine transplantation training and improve the transplantation success rate in humans.http://www.ekjt.org/journal/view.html?doi=10.4285/kjt.23.0019infertility; uterus; transplantation; living donor; dogs |
| spellingShingle | Xuan-Hai Do Thanh-Hai Tong Trung-Chuc Nguyen Tuan-Anh Ngo Minh-Trang Thi Tran Anatomic characteristics and novel transplantation model of the canine uterus Korean Journal of Transplantation infertility; uterus; transplantation; living donor; dogs |
| title | Anatomic characteristics and novel transplantation model of the canine uterus |
| title_full | Anatomic characteristics and novel transplantation model of the canine uterus |
| title_fullStr | Anatomic characteristics and novel transplantation model of the canine uterus |
| title_full_unstemmed | Anatomic characteristics and novel transplantation model of the canine uterus |
| title_short | Anatomic characteristics and novel transplantation model of the canine uterus |
| title_sort | anatomic characteristics and novel transplantation model of the canine uterus |
| topic | infertility; uterus; transplantation; living donor; dogs |
| url | http://www.ekjt.org/journal/view.html?doi=10.4285/kjt.23.0019 |
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