An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort
Background: Atopic Dermatitis (AD) is a highly pruritic, chronic-recurrent inflammatory skin condition associated with erythematous lesions that affect a significant proportion of the population. Although AD is a non-communicable disease, it can cause pain, unbearable itchiness, sleep disturbance, l...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455122000989 |
| _version_ | 1798006126726348800 |
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| author | Jun Jie Lim, BSc(Hons) Ying Yi Eliza Lim, BSc(Hons) Jun Yan Ng, BSc(Hons) Praneeth Malipeddi, MSc Yu Ting Ng, BSc(Hons) Wei Yi Teo, BSc(Hons) Qi Yi Ambrose Wong, BSc(Hons) Sri Anusha Matta, PhD Yang Yie Sio, PhD Yi Ru Wong, BSc(Hons) Keng Foo Teh, BSc(Hons) Smyrna Moti Rawanan Shah, BSc(Hons) Kavita Reginald, PhD Yee-How Say, PhD Fook Tim Chew, PhD |
| author_facet | Jun Jie Lim, BSc(Hons) Ying Yi Eliza Lim, BSc(Hons) Jun Yan Ng, BSc(Hons) Praneeth Malipeddi, MSc Yu Ting Ng, BSc(Hons) Wei Yi Teo, BSc(Hons) Qi Yi Ambrose Wong, BSc(Hons) Sri Anusha Matta, PhD Yang Yie Sio, PhD Yi Ru Wong, BSc(Hons) Keng Foo Teh, BSc(Hons) Smyrna Moti Rawanan Shah, BSc(Hons) Kavita Reginald, PhD Yee-How Say, PhD Fook Tim Chew, PhD |
| author_sort | Jun Jie Lim, BSc(Hons) |
| collection | DOAJ |
| description | Background: Atopic Dermatitis (AD) is a highly pruritic, chronic-recurrent inflammatory skin condition associated with erythematous lesions that affect a significant proportion of the population. Although AD is a non-communicable disease, it can cause pain, unbearable itchiness, sleep disturbance, loss of work productivity, and reduced quality of life. As a heterogeneous disease, AD is influenced by multiple genes and environmental triggers. As such, it is imperative to gain a deeper insight into the intricate gene-environment relationship that results in the manifestation of AD. Methods: There are 3 objectives in our study. We first aim to update the epidemiological status of AD amongst young adults in Singapore and Malaysia, in particular amongst the Chinese ethnic background. Next, we re-evaluated the possible associated risk factors, identified in our previous meta-analysis and review studies, on the current cohort. Finally, we described here a detailed disease presentation and symptoms profile of our Singapore and Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort, which forms the base population for the discovery of associated genetic factors in relation to asthma, allergic diseases and skin conditions. Based on a skin prick test (SPT) and investigator-administered medical history responses, we assessed the AD profiles of 11 494 participants and the significant modifiable and non-modifiable factors associated with disease presentation. Results: The prevalence of AD in the combined population was 13.5%. Chronic and moderate/severe AD were observed in 35.5% and 40.5% of the individuals with AD, respectively. Family history of atopic diseases, prior history of drug allergies, a history of acne, increased household family monthly income, higher number of individuals in the shared household, parental education, sedentary lifestyle, physical activities, alcoholic consumption, and even quality of diet was significantly associated with AD presentation, chronicity, and severity. Among all the factors evaluated, family and personal history of atopic diseases imposed the strongest associated risk. Conclusions: These findings supported our previous review studies and affirmed that familial history or genetic factors critically influence the development of AD in our population and environment. Environmental and other modifiable factors can also trigger AD throughout the lifetime of individuals who have especially inherited the atopic disease disposition. A better understanding of how these risk factors affect AD individuals in our population can facilitate disease surveillance, monitor disease control, and serve as a description for our future genetic epidemiology studies. |
| first_indexed | 2024-04-11T12:50:09Z |
| format | Article |
| id | doaj.art-d0bbff3fb3c94141bded3a00bc02772b |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-11T12:50:09Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-d0bbff3fb3c94141bded3a00bc02772b2022-12-22T04:23:14ZengElsevierWorld Allergy Organization Journal1939-45512022-12-011512100722An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohortJun Jie Lim, BSc(Hons)0Ying Yi Eliza Lim, BSc(Hons)1Jun Yan Ng, BSc(Hons)2Praneeth Malipeddi, MSc3Yu Ting Ng, BSc(Hons)4Wei Yi Teo, BSc(Hons)5Qi Yi Ambrose Wong, BSc(Hons)6Sri Anusha Matta, PhD7Yang Yie Sio, PhD8Yi Ru Wong, BSc(Hons)9Keng Foo Teh, BSc(Hons)10Smyrna Moti Rawanan Shah, BSc(Hons)11Kavita Reginald, PhD12Yee-How Say, PhD13Fook Tim Chew, PhD14Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, SingaporeDepartment of Biological Sciences, School of Medicine and Life Sciences, Sunway University Petaling Jaya, 47500, Selangor, MalaysiaDepartment of Biological Sciences, School of Medicine and Life Sciences, Sunway University Petaling Jaya, 47500, Selangor, MalaysiaDepartment of Biological Sciences, School of Medicine and Life Sciences, Sunway University Petaling Jaya, 47500, Selangor, MalaysiaDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore; Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University Petaling Jaya, 47500, Selangor, MalaysiaDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore; Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University Petaling Jaya, 47500, Selangor, Malaysia; Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR) Kampar, Perak, 31900, MalaysiaDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore; Corresponding author. Department of Biological Sciences; Vice Dean, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore 117543, SingaporeBackground: Atopic Dermatitis (AD) is a highly pruritic, chronic-recurrent inflammatory skin condition associated with erythematous lesions that affect a significant proportion of the population. Although AD is a non-communicable disease, it can cause pain, unbearable itchiness, sleep disturbance, loss of work productivity, and reduced quality of life. As a heterogeneous disease, AD is influenced by multiple genes and environmental triggers. As such, it is imperative to gain a deeper insight into the intricate gene-environment relationship that results in the manifestation of AD. Methods: There are 3 objectives in our study. We first aim to update the epidemiological status of AD amongst young adults in Singapore and Malaysia, in particular amongst the Chinese ethnic background. Next, we re-evaluated the possible associated risk factors, identified in our previous meta-analysis and review studies, on the current cohort. Finally, we described here a detailed disease presentation and symptoms profile of our Singapore and Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort, which forms the base population for the discovery of associated genetic factors in relation to asthma, allergic diseases and skin conditions. Based on a skin prick test (SPT) and investigator-administered medical history responses, we assessed the AD profiles of 11 494 participants and the significant modifiable and non-modifiable factors associated with disease presentation. Results: The prevalence of AD in the combined population was 13.5%. Chronic and moderate/severe AD were observed in 35.5% and 40.5% of the individuals with AD, respectively. Family history of atopic diseases, prior history of drug allergies, a history of acne, increased household family monthly income, higher number of individuals in the shared household, parental education, sedentary lifestyle, physical activities, alcoholic consumption, and even quality of diet was significantly associated with AD presentation, chronicity, and severity. Among all the factors evaluated, family and personal history of atopic diseases imposed the strongest associated risk. Conclusions: These findings supported our previous review studies and affirmed that familial history or genetic factors critically influence the development of AD in our population and environment. Environmental and other modifiable factors can also trigger AD throughout the lifetime of individuals who have especially inherited the atopic disease disposition. A better understanding of how these risk factors affect AD individuals in our population can facilitate disease surveillance, monitor disease control, and serve as a description for our future genetic epidemiology studies.http://www.sciencedirect.com/science/article/pii/S1939455122000989Atopic dermatitisRisk factorsEpidemiologyEthnic ChineseSingapore/Malaysia |
| spellingShingle | Jun Jie Lim, BSc(Hons) Ying Yi Eliza Lim, BSc(Hons) Jun Yan Ng, BSc(Hons) Praneeth Malipeddi, MSc Yu Ting Ng, BSc(Hons) Wei Yi Teo, BSc(Hons) Qi Yi Ambrose Wong, BSc(Hons) Sri Anusha Matta, PhD Yang Yie Sio, PhD Yi Ru Wong, BSc(Hons) Keng Foo Teh, BSc(Hons) Smyrna Moti Rawanan Shah, BSc(Hons) Kavita Reginald, PhD Yee-How Say, PhD Fook Tim Chew, PhD An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort World Allergy Organization Journal Atopic dermatitis Risk factors Epidemiology Ethnic Chinese Singapore/Malaysia |
| title | An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort |
| title_full | An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort |
| title_fullStr | An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort |
| title_full_unstemmed | An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort |
| title_short | An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort |
| title_sort | update on the prevalence chronicity and severity of atopic dermatitis and the associated epidemiological risk factors in the singapore malaysia chinese young adult population a detailed description of the singapore malaysia cross sectional genetics epidemiology study smcges cohort |
| topic | Atopic dermatitis Risk factors Epidemiology Ethnic Chinese Singapore/Malaysia |
| url | http://www.sciencedirect.com/science/article/pii/S1939455122000989 |
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