Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota
Resveratrol is a natural polyphenol that has anti-aging and anti-inflammatory properties against stress condition. It is reported that resveratrol has beneficial functions in various metabolic and central nervous system (CNS) diseases, such as obesity, diabetes, depression, and dementia. Recently, m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2020.588044/full |
| _version_ | 1818242287744843776 |
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| author | Ji Yeon Chung Jae-Ho Jeong Juhyun Song |
| author_facet | Ji Yeon Chung Jae-Ho Jeong Juhyun Song |
| author_sort | Ji Yeon Chung |
| collection | DOAJ |
| description | Resveratrol is a natural polyphenol that has anti-aging and anti-inflammatory properties against stress condition. It is reported that resveratrol has beneficial functions in various metabolic and central nervous system (CNS) diseases, such as obesity, diabetes, depression, and dementia. Recently, many researchers have emphasized the connection between the brain and gut, called the gut–brain axis, for treating both CNS neuropathologies and gastrointestinal diseases. Based on previous findings, resveratrol is involved in glucagon-like peptide 1 (GLP-1) secreted by intestine L cells, the patterns of microbiome in the intestine, the 5-hydroxytryptamine (5-HT) level, and CNS inflammation. Here, we review recent evidences concerning the relevance and regulatory function of resveratrol in the gut–brain axis from various perspectives. Here, we highlight the necessity for further study on resveratrol's specific mechanism in the gut–brain axis. We present the potential of resveratrol as a natural therapeutic substance for treating both neuropathology and gastrointestinal dysfunction. |
| first_indexed | 2024-12-12T13:42:50Z |
| format | Article |
| id | doaj.art-d0bcd7ee932044f5bd3296ad12416171 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T13:42:50Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-d0bcd7ee932044f5bd3296ad124161712022-12-22T00:22:45ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-11-011210.3389/fnagi.2020.588044588044Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut MicrobiotaJi Yeon Chung0Jae-Ho Jeong1Juhyun Song2Department of Neurology, Chosun University Medical School, Gwangju, South KoreaDepartment of Microbiology, Chonnam National University Medical School, Gwangju, South KoreaDepartment of Anatomy, Chonnam National University Medical School, Gwangju, South KoreaResveratrol is a natural polyphenol that has anti-aging and anti-inflammatory properties against stress condition. It is reported that resveratrol has beneficial functions in various metabolic and central nervous system (CNS) diseases, such as obesity, diabetes, depression, and dementia. Recently, many researchers have emphasized the connection between the brain and gut, called the gut–brain axis, for treating both CNS neuropathologies and gastrointestinal diseases. Based on previous findings, resveratrol is involved in glucagon-like peptide 1 (GLP-1) secreted by intestine L cells, the patterns of microbiome in the intestine, the 5-hydroxytryptamine (5-HT) level, and CNS inflammation. Here, we review recent evidences concerning the relevance and regulatory function of resveratrol in the gut–brain axis from various perspectives. Here, we highlight the necessity for further study on resveratrol's specific mechanism in the gut–brain axis. We present the potential of resveratrol as a natural therapeutic substance for treating both neuropathology and gastrointestinal dysfunction.https://www.frontiersin.org/articles/10.3389/fnagi.2020.588044/fullresveratrolgut–brain axisglucagon-like peptide-1 (GLP-1)5-hydroxytryptamine (5-HT)gut microbiota |
| spellingShingle | Ji Yeon Chung Jae-Ho Jeong Juhyun Song Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota Frontiers in Aging Neuroscience resveratrol gut–brain axis glucagon-like peptide-1 (GLP-1) 5-hydroxytryptamine (5-HT) gut microbiota |
| title | Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota |
| title_full | Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota |
| title_fullStr | Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota |
| title_full_unstemmed | Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota |
| title_short | Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota |
| title_sort | resveratrol modulates the gut brain axis focus on glucagon like peptide 1 5 ht and gut microbiota |
| topic | resveratrol gut–brain axis glucagon-like peptide-1 (GLP-1) 5-hydroxytryptamine (5-HT) gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2020.588044/full |
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