Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation

Autoimmune destruction of pancreatic beta cells causes absolute insulin deficiency and results in type 1 diabetes mellitus (T1DM). The substitution of healthy pancreatic beta cells for damaged cells would be the ideal treatment for T1DM; thus, the generation of pancreatic beta cells from adult stem...

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Bibliographic Details
Main Authors: Yuhua Gao, Ranxi Zhang, Shanshan Dai, Xue Zhang, Xiangchen Li, Chunyu Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pancreatic beta cells
stem cells
TGF-β/Smad pathway
Ngn3
microRNAs
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00351/full

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