Safety, immunogenicity, and lot-to-lot consistency of a multidose Sabin strain-based inactivated polio vaccine: a phase III, randomized, blinded, positive-control clinical trial in infants aged 2 months

Safety, immunogenicity, and lot-to-lot consistency of a multidose Sabin strain-based inactivated polio vaccine: a phase III, randomized, blinded, positive-control clinical trial in infants aged 2 months

ABSTRACT: Objectives: To evaluate the safety, immunogenicity, and lot-to-lot consistency of Sabin strain-based inactivated polio vaccine (sIPV) in a five-dose vial presentation. Methods: Stage I was an open-label safety observation, in which 72 healthy subjects (including 24 adults, children, and i...

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Bibliographic Details
Main Authors: Guangwei Feng, Deyu Jiang, Weixiao Han, Zhiqiang Xie, Zhiwei Jiang, Lili Huang, Jianfeng Wang, Wei Zhang, Li Xu, Jiebing Tan, Wangyang You, Guoliang Cui, Changgui Li, Yanxia Wang
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:International Journal of Infectious Diseases
Subjects:
Sabin strain
Inactivated poliovirus vaccine
Lot-to-lot consistency
Phase-III trial
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971223000206

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