Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells
There is recent interest in a diet that can be recommended for patients suffering from cancer. In this respect, the effects were studied of the extracts of several common fruits, herbs and vegetables on the viability of two human ovary cancer cell lines (SKOV-3 and PEO1) in vitro. Normal human MRC-5...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/11/16/2518 |
| _version_ | 1797445428843642880 |
|---|---|
| author | Paulina Furdak Natalia Pieńkowska Grzegorz Bartosz Izabela Sadowska-Bartosz |
| author_facet | Paulina Furdak Natalia Pieńkowska Grzegorz Bartosz Izabela Sadowska-Bartosz |
| author_sort | Paulina Furdak |
| collection | DOAJ |
| description | There is recent interest in a diet that can be recommended for patients suffering from cancer. In this respect, the effects were studied of the extracts of several common fruits, herbs and vegetables on the viability of two human ovary cancer cell lines (SKOV-3 and PEO1) in vitro. Normal human MRC-5 fibroblasts were used as a control cell line. The extracts of garlic, horseradish and curly kale as well as green and black tea were the most effective in lowering the viability of ovarian cancer cells, while not affecting the viability of MRC-5 fibroblasts. Except for garlic and horseradish, the cytotoxic effects of the extracts correlated with their polyphenol content. The examination of changes in the content of ATP and glutathione, in the level of reactive oxygen species, mitochondrial potential and mitochondrial mass did not show a consistent pattern, suggesting that various extracts may act via different mechanisms. Although the extracts’ toxicity to cells in vitro is a first and direct suggestion concerning their possible anticancer effects in vivo, these results point to potential vegetable candidates to become diet components recommended for ovary cancer patients. |
| first_indexed | 2024-03-09T13:26:39Z |
| format | Article |
| id | doaj.art-d0bf473df6ad4b6ca150870e352297c4 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T13:26:39Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-d0bf473df6ad4b6ca150870e352297c42023-11-30T21:23:52ZengMDPI AGFoods2304-81582022-08-011116251810.3390/foods11162518Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer CellsPaulina Furdak0Natalia Pieńkowska1Grzegorz Bartosz2Izabela Sadowska-Bartosz3Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, 4 Zelwerowicza Street, 35-601 Rzeszow, PolandLaboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, 4 Zelwerowicza Street, 35-601 Rzeszow, PolandLaboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, 4 Zelwerowicza Street, 35-601 Rzeszow, PolandLaboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, 4 Zelwerowicza Street, 35-601 Rzeszow, PolandThere is recent interest in a diet that can be recommended for patients suffering from cancer. In this respect, the effects were studied of the extracts of several common fruits, herbs and vegetables on the viability of two human ovary cancer cell lines (SKOV-3 and PEO1) in vitro. Normal human MRC-5 fibroblasts were used as a control cell line. The extracts of garlic, horseradish and curly kale as well as green and black tea were the most effective in lowering the viability of ovarian cancer cells, while not affecting the viability of MRC-5 fibroblasts. Except for garlic and horseradish, the cytotoxic effects of the extracts correlated with their polyphenol content. The examination of changes in the content of ATP and glutathione, in the level of reactive oxygen species, mitochondrial potential and mitochondrial mass did not show a consistent pattern, suggesting that various extracts may act via different mechanisms. Although the extracts’ toxicity to cells in vitro is a first and direct suggestion concerning their possible anticancer effects in vivo, these results point to potential vegetable candidates to become diet components recommended for ovary cancer patients.https://www.mdpi.com/2304-8158/11/16/2518ovary cancerSKOV-3PEO1cytotoxicitypolyphenolshorseradish |
| spellingShingle | Paulina Furdak Natalia Pieńkowska Grzegorz Bartosz Izabela Sadowska-Bartosz Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells Foods ovary cancer SKOV-3 PEO1 cytotoxicity polyphenols horseradish |
| title | Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells |
| title_full | Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells |
| title_fullStr | Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells |
| title_full_unstemmed | Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells |
| title_short | Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells |
| title_sort | extracts of common vegetables inhibit the growth of ovary cancer cells |
| topic | ovary cancer SKOV-3 PEO1 cytotoxicity polyphenols horseradish |
| url | https://www.mdpi.com/2304-8158/11/16/2518 |
| work_keys_str_mv | AT paulinafurdak extractsofcommonvegetablesinhibitthegrowthofovarycancercells AT nataliapienkowska extractsofcommonvegetablesinhibitthegrowthofovarycancercells AT grzegorzbartosz extractsofcommonvegetablesinhibitthegrowthofovarycancercells AT izabelasadowskabartosz extractsofcommonvegetablesinhibitthegrowthofovarycancercells |