Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
Abstract One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | npj Regenerative Medicine |
| Online Access: | https://doi.org/10.1038/s41536-021-00127-1 |
| _version_ | 1818845741243695104 |
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| author | Anselmo Moriscot Elen H. Miyabara Bruno Langeani Antonio Belli Stuart Egginton T. Scott Bowen |
| author_facet | Anselmo Moriscot Elen H. Miyabara Bruno Langeani Antonio Belli Stuart Egginton T. Scott Bowen |
| author_sort | Anselmo Moriscot |
| collection | DOAJ |
| description | Abstract One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence. |
| first_indexed | 2024-12-19T05:34:28Z |
| format | Article |
| id | doaj.art-d0bfc0cd1d7d45ddb22bc0e83d0de854 |
| institution | Directory Open Access Journal |
| issn | 2057-3995 |
| language | English |
| last_indexed | 2024-12-19T05:34:28Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Regenerative Medicine |
| spelling | doaj.art-d0bfc0cd1d7d45ddb22bc0e83d0de8542022-12-21T20:34:09ZengNature Portfolionpj Regenerative Medicine2057-39952021-03-016111710.1038/s41536-021-00127-1Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regenerationAnselmo Moriscot0Elen H. Miyabara1Bruno Langeani2Antonio Belli3Stuart Egginton4T. Scott Bowen5Department of Anatomy, Institute of Biomedical Sciences, University of São PauloDepartment of Anatomy, Institute of Biomedical Sciences, University of São PauloSou da Paz InstituteNIHR Surgical Reconstruction and Microbiology Research Centre, University of BirminghamSchool of Biomedical Sciences, Faculty of Biological Sciences, University of LeedsSchool of Biomedical Sciences, Faculty of Biological Sciences, University of LeedsAbstract One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence.https://doi.org/10.1038/s41536-021-00127-1 |
| spellingShingle | Anselmo Moriscot Elen H. Miyabara Bruno Langeani Antonio Belli Stuart Egginton T. Scott Bowen Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration npj Regenerative Medicine |
| title | Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration |
| title_full | Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration |
| title_fullStr | Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration |
| title_full_unstemmed | Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration |
| title_short | Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration |
| title_sort | firearms related skeletal muscle trauma pathophysiology and novel approaches for regeneration |
| url | https://doi.org/10.1038/s41536-021-00127-1 |
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