Structural biology and functional features of phage-derived depolymerase Depo32 on Klebsiella pneumoniae with K2 serotype capsular polysaccharides

Structural biology and functional features of phage-derived depolymerase Depo32 on Klebsiella pneumoniae with K2 serotype capsular polysaccharides

ABSTRACT Hypervirulent Klebsiella pneumoniae with capsular polysaccharides (CPSs) causes severe nosocomial- and community-acquired infections. Phage-derived depolymerases can degrade CPSs from K. pneumoniae to attenuate bacterial virulence, but their antimicrobial mechanisms and clinical potential a...

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Bibliographic Details
Main Authors: Ruopeng Cai, Zhuolu Ren, Rihong Zhao, Yan Lu, Xinwu Wang, Zhimin Guo, Jinming Song, Wentao Xiang, Rui Du, Xiaokang Zhang, Wenyu Han, Heng Ru, Jingmin Gu
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
depolymerase
Klebsiella pneumoniae
K2 capsular type
structural biology
therapeutic effect
Online Access:https://journals.asm.org/doi/10.1128/spectrum.05304-22

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