Single Nucleotide Polymorphism of IL-2 Gene at Position +166 in Type 1 Diabetes of Iraqi Patients
The present study aimed at investigating of frequency of polymorphism of interleukin-2 gene (IL2) at position+166 SNP) in Type 1 Diabetes and in healthy controls subjects 39 of Iraqi patients, (12 males & 27 females;1 5.65 ± 1.79 years) and 21 controls.(7 mail & 14 female ; 14.66 ± 3.43 yea...
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| Format: | Article |
| Language: | English |
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University of Thi-Qar
2020-12-01
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| Series: | مجلة علوم ذي قار |
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| Online Access: | https://jsci.utq.edu.iq/index.php/main/article/view/703 |
| _version_ | 1827766090216767488 |
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| author | Ibtesam, B. Hassan |
| author_facet | Ibtesam, B. Hassan |
| author_sort | Ibtesam, B. Hassan |
| collection | DOAJ |
| description |
The present study aimed at investigating of frequency of polymorphism of interleukin-2 gene (IL2) at position+166 SNP) in Type 1 Diabetes and in healthy controls subjects 39 of Iraqi patients, (12 males & 27 females;1 5.65 ± 1.79 years) and 21 controls.(7 mail & 14 female ; 14.66 ± 3.43 years) attended the hospital in Baghdad for diagnosis and treatment during the period February 2015 – January 2016 were enrolled in this study, the polymorphism of IL2+166 was data waved by polymerase chain reaction-specific sequence primer (PCR-SSP) assay. The results showed a comparison IL2+166 genotypes & alleles between T1D patients & controls frequencies of TT genotype & T allele (71.69vs. 68.95%;P =0.589 respectively) There was a significant increase in patients contrast to controls, (51.38vs. 48.08%; P =0.312) and associated RR rates were 19.2% & 27.0%, respectively. And the related EF values were 1.56 & 1.60 .Similar observations were made in GG genotype. In contrast TG genotype & G allele (23.93 vs. 28.55%,P =1.000 respectively) Low frequency was observed in patients compared to healthy subjects (43.28 vs. 43.22%; P =0.312), and the related PF values were 0.56 & 0.62 , respectively. The results of the study indicate that IL2+166 SNP may have a role in the mechanism of etiopathogenic of T1D in the samples of Iraqi patients
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| first_indexed | 2024-03-11T11:37:01Z |
| format | Article |
| id | doaj.art-d0c29385a2df4fd198788aee185843a1 |
| institution | Directory Open Access Journal |
| issn | 1991-8690 2709-0256 |
| language | English |
| last_indexed | 2024-03-11T11:37:01Z |
| publishDate | 2020-12-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj.art-d0c29385a2df4fd198788aee185843a12023-11-10T13:21:17ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562020-12-0172Single Nucleotide Polymorphism of IL-2 Gene at Position +166 in Type 1 Diabetes of Iraqi PatientsIbtesam, B. Hassan The present study aimed at investigating of frequency of polymorphism of interleukin-2 gene (IL2) at position+166 SNP) in Type 1 Diabetes and in healthy controls subjects 39 of Iraqi patients, (12 males & 27 females;1 5.65 ± 1.79 years) and 21 controls.(7 mail & 14 female ; 14.66 ± 3.43 years) attended the hospital in Baghdad for diagnosis and treatment during the period February 2015 – January 2016 were enrolled in this study, the polymorphism of IL2+166 was data waved by polymerase chain reaction-specific sequence primer (PCR-SSP) assay. The results showed a comparison IL2+166 genotypes & alleles between T1D patients & controls frequencies of TT genotype & T allele (71.69vs. 68.95%;P =0.589 respectively) There was a significant increase in patients contrast to controls, (51.38vs. 48.08%; P =0.312) and associated RR rates were 19.2% & 27.0%, respectively. And the related EF values were 1.56 & 1.60 .Similar observations were made in GG genotype. In contrast TG genotype & G allele (23.93 vs. 28.55%,P =1.000 respectively) Low frequency was observed in patients compared to healthy subjects (43.28 vs. 43.22%; P =0.312), and the related PF values were 0.56 & 0.62 , respectively. The results of the study indicate that IL2+166 SNP may have a role in the mechanism of etiopathogenic of T1D in the samples of Iraqi patients https://jsci.utq.edu.iq/index.php/main/article/view/703Polymorphism, IL-2, T1D, |
| spellingShingle | Ibtesam, B. Hassan Single Nucleotide Polymorphism of IL-2 Gene at Position +166 in Type 1 Diabetes of Iraqi Patients مجلة علوم ذي قار Polymorphism, IL-2, T1D, |
| title | Single Nucleotide Polymorphism of IL-2 Gene at Position +166 in Type 1 Diabetes of Iraqi Patients |
| title_full | Single Nucleotide Polymorphism of IL-2 Gene at Position +166 in Type 1 Diabetes of Iraqi Patients |
| title_fullStr | Single Nucleotide Polymorphism of IL-2 Gene at Position +166 in Type 1 Diabetes of Iraqi Patients |
| title_full_unstemmed | Single Nucleotide Polymorphism of IL-2 Gene at Position +166 in Type 1 Diabetes of Iraqi Patients |
| title_short | Single Nucleotide Polymorphism of IL-2 Gene at Position +166 in Type 1 Diabetes of Iraqi Patients |
| title_sort | single nucleotide polymorphism of il 2 gene at position 166 in type 1 diabetes of iraqi patients |
| topic | Polymorphism, IL-2, T1D, |
| url | https://jsci.utq.edu.iq/index.php/main/article/view/703 |
| work_keys_str_mv | AT ibtesambhassan singlenucleotidepolymorphismofil2geneatposition166intype1diabetesofiraqipatients |