Immunological Response during Pregnancy in Humans and Mares
The immunology of pregnancy deals with the immune responses of a mother and her fetus to each other. More knowledge has been acquired over the last decade to give insight into the complicated immunological processes that help the developing fetus to survive in most circumstances. During this unusual...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Agriculture |
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| Online Access: | https://www.mdpi.com/2077-0472/12/3/431 |
| _version_ | 1797473399569645568 |
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| author | Aleksandra Figarska Olga Witkowska-Piłaszewicz |
| author_facet | Aleksandra Figarska Olga Witkowska-Piłaszewicz |
| author_sort | Aleksandra Figarska |
| collection | DOAJ |
| description | The immunology of pregnancy deals with the immune responses of a mother and her fetus to each other. More knowledge has been acquired over the last decade to give insight into the complicated immunological processes that help the developing fetus to survive in most circumstances. During this unusual state, the mother’s immune system must remain tolerant to paternal major histocompatibility complex (MHC) antigens while retaining normal immunological competence for pathogen defense, which is a difficult act. In the last decade, numerous processes have been revealed that may explain why the mother does not reject the foreign fetus. To understand how these processes work, the need to look at both fetal and maternal aspects, including trophoblast cell characteristics, local maternal factors, and changed MHC class I expression, is required. Horses, because of their unique anatomy and physiology, are a very useful animal model in pregnancy immunology research. In pregnant mares, chorionic girdle cells generate cytotoxic antibodies to paternal MHC class I antigens, enabling a more in-depth study of these invasive trophoblasts and their effect on the mother’s immune system. Therefore, this review will concentrate on the immune response during pregnancy in both humans and horses. |
| first_indexed | 2024-03-09T20:13:58Z |
| format | Article |
| id | doaj.art-d0c3079bac804f1ba49df6e81fe59087 |
| institution | Directory Open Access Journal |
| issn | 2077-0472 |
| language | English |
| last_indexed | 2024-03-09T20:13:58Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Agriculture |
| spelling | doaj.art-d0c3079bac804f1ba49df6e81fe590872023-11-24T00:06:15ZengMDPI AGAgriculture2077-04722022-03-0112343110.3390/agriculture12030431Immunological Response during Pregnancy in Humans and MaresAleksandra Figarska0Olga Witkowska-Piłaszewicz1Department of Large Animals Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences—SGGW, 02-776 Warsaw, PolandDepartment of Large Animals Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences—SGGW, 02-776 Warsaw, PolandThe immunology of pregnancy deals with the immune responses of a mother and her fetus to each other. More knowledge has been acquired over the last decade to give insight into the complicated immunological processes that help the developing fetus to survive in most circumstances. During this unusual state, the mother’s immune system must remain tolerant to paternal major histocompatibility complex (MHC) antigens while retaining normal immunological competence for pathogen defense, which is a difficult act. In the last decade, numerous processes have been revealed that may explain why the mother does not reject the foreign fetus. To understand how these processes work, the need to look at both fetal and maternal aspects, including trophoblast cell characteristics, local maternal factors, and changed MHC class I expression, is required. Horses, because of their unique anatomy and physiology, are a very useful animal model in pregnancy immunology research. In pregnant mares, chorionic girdle cells generate cytotoxic antibodies to paternal MHC class I antigens, enabling a more in-depth study of these invasive trophoblasts and their effect on the mother’s immune system. Therefore, this review will concentrate on the immune response during pregnancy in both humans and horses.https://www.mdpi.com/2077-0472/12/3/431immunologypregnancyhorsemarehumanimmunological responses |
| spellingShingle | Aleksandra Figarska Olga Witkowska-Piłaszewicz Immunological Response during Pregnancy in Humans and Mares Agriculture immunology pregnancy horse mare human immunological responses |
| title | Immunological Response during Pregnancy in Humans and Mares |
| title_full | Immunological Response during Pregnancy in Humans and Mares |
| title_fullStr | Immunological Response during Pregnancy in Humans and Mares |
| title_full_unstemmed | Immunological Response during Pregnancy in Humans and Mares |
| title_short | Immunological Response during Pregnancy in Humans and Mares |
| title_sort | immunological response during pregnancy in humans and mares |
| topic | immunology pregnancy horse mare human immunological responses |
| url | https://www.mdpi.com/2077-0472/12/3/431 |
| work_keys_str_mv | AT aleksandrafigarska immunologicalresponseduringpregnancyinhumansandmares AT olgawitkowskapiłaszewicz immunologicalresponseduringpregnancyinhumansandmares |