Modification of bacterial effector proteins inside eukaryotic host cells
Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins -called effectors- directly into the plant or animal cells. Recent findings have shown that such effectors can suffer covalent modifications inside the eukaryotic cells. Here, we summarize the recent reports wher...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00073/full |
| _version_ | 1819142784552009728 |
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| author | Crina Mihaela Popa Crina Mihaela Popa Mitsuaki Tabuchi Marc Valls Marc Valls |
| author_facet | Crina Mihaela Popa Crina Mihaela Popa Mitsuaki Tabuchi Marc Valls Marc Valls |
| author_sort | Crina Mihaela Popa |
| collection | DOAJ |
| description | Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins -called effectors- directly into the plant or animal cells. Recent findings have shown that such effectors can suffer covalent modifications inside the eukaryotic cells. Here, we summarize the recent reports where effector modifications by the eukaryotic machinery have been described. We restrict our focus on proteins secreted by the type III or type IV systems, excluding other bacterial toxins. We describe the known examples of effectors whose enzymatic activity is triggered by interaction with plant and animal cell factors, including GTPases, E2-Ubiquitin conjugates, phosphatases, cyclophilin and thioredoxins. We focus on the structural interactions with these factors and their influence on effector function. We also review the described examples of host-mediated post-translational effector modifications which are required for proper subcellular location and function. These host-specific covalent modifications include phosphorylation, ubiquitination, sumoylation and lipidations such as prenylation, fatty acylation and phospholipid binding. |
| first_indexed | 2024-12-22T12:15:51Z |
| format | Article |
| id | doaj.art-d0c33e065b9b46cfb15a76ea99646015 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T12:15:51Z |
| publishDate | 2016-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-d0c33e065b9b46cfb15a76ea996460152022-12-21T18:26:09ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882016-07-01610.3389/fcimb.2016.00073212574Modification of bacterial effector proteins inside eukaryotic host cellsCrina Mihaela Popa0Crina Mihaela Popa1Mitsuaki Tabuchi2Marc Valls3Marc Valls4Universitat de BarcelonaCenter for research ion Agricultural Genomics (CRAG, CSIC-IRTA-UAB-UB)Kagawa UniversityUniversitat de BarcelonaCenter for research ion Agricultural Genomics (CRAG, CSIC-IRTA-UAB-UB)Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins -called effectors- directly into the plant or animal cells. Recent findings have shown that such effectors can suffer covalent modifications inside the eukaryotic cells. Here, we summarize the recent reports where effector modifications by the eukaryotic machinery have been described. We restrict our focus on proteins secreted by the type III or type IV systems, excluding other bacterial toxins. We describe the known examples of effectors whose enzymatic activity is triggered by interaction with plant and animal cell factors, including GTPases, E2-Ubiquitin conjugates, phosphatases, cyclophilin and thioredoxins. We focus on the structural interactions with these factors and their influence on effector function. We also review the described examples of host-mediated post-translational effector modifications which are required for proper subcellular location and function. These host-specific covalent modifications include phosphorylation, ubiquitination, sumoylation and lipidations such as prenylation, fatty acylation and phospholipid binding.http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00073/fulltype III secretion systemeukaryotic hosttype IV secretion systembacterial virulenceAnimal pathogensBacterial effector |
| spellingShingle | Crina Mihaela Popa Crina Mihaela Popa Mitsuaki Tabuchi Marc Valls Marc Valls Modification of bacterial effector proteins inside eukaryotic host cells Frontiers in Cellular and Infection Microbiology type III secretion system eukaryotic host type IV secretion system bacterial virulence Animal pathogens Bacterial effector |
| title | Modification of bacterial effector proteins inside eukaryotic host cells |
| title_full | Modification of bacterial effector proteins inside eukaryotic host cells |
| title_fullStr | Modification of bacterial effector proteins inside eukaryotic host cells |
| title_full_unstemmed | Modification of bacterial effector proteins inside eukaryotic host cells |
| title_short | Modification of bacterial effector proteins inside eukaryotic host cells |
| title_sort | modification of bacterial effector proteins inside eukaryotic host cells |
| topic | type III secretion system eukaryotic host type IV secretion system bacterial virulence Animal pathogens Bacterial effector |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00073/full |
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