A Lactose‐Derived CRISPR/Cas9 Delivery System for Efficient Genome Editing In Vivo to Treat Orthotopic Hepatocellular Carcinoma

A Lactose‐Derived CRISPR/Cas9 Delivery System for Efficient Genome Editing In Vivo to Treat Orthotopic Hepatocellular Carcinoma

Abstract Gene editing is a crucial and effective strategy to treat genetic diseases. Safe and effective delivery vectors are specially required for efficient gene editing in vivo of CRISPR/Cas9 system. Interestingly, lactose, a natural saccharide, can specifically bind to asialoglycoprotein receptor...

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Bibliographic Details
Main Authors: Yu Qi, Yanli Liu, Bingran Yu, Yang Hu, Nasha Zhang, Yan Zheng, Ming Yang, Fu‐Jian Xu
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Advanced Science
Subjects:
biopolymers
CRISPR/Cas9
delivery vectors
lactose
orthotopic hepatocellular carcinoma
Online Access:https://doi.org/10.1002/advs.202001424

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