Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture
Although common in clinical practice, bleeding after tissue puncture may cause serious outcomes, especially in arterial puncture. Herein, gelatin-tannic acid composite hydrogels with varying compositions are prepared, and their adhesive properties are further optimized in microfluidic channel-based...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2022-06-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21004680 |
| _version_ | 1797204836169547776 |
|---|---|
| author | Xingjie Yin Jingli Ren Wei Lan Yu Chen Mengping Ouyang Hua Su Lianbin Zhang Jintao Zhu Chun Zhang |
| author_facet | Xingjie Yin Jingli Ren Wei Lan Yu Chen Mengping Ouyang Hua Su Lianbin Zhang Jintao Zhu Chun Zhang |
| author_sort | Xingjie Yin |
| collection | DOAJ |
| description | Although common in clinical practice, bleeding after tissue puncture may cause serious outcomes, especially in arterial puncture. Herein, gelatin-tannic acid composite hydrogels with varying compositions are prepared, and their adhesive properties are further optimized in microfluidic channel-based simulated vessels for haemostasis in arterial puncture. It is revealed that the composite hydrogels on the syringe needles used for arterial puncture should possess underwater adhesion higher than 4.9 kPa and mechanical strength higher than 86.0 kPa. The needles coated with the gelatin-tannic acid composite hydrogel completely prevent blood loss after both vein and arterial puncture in different animal models. This study holds great significance for the preparation of haemostatic needles for vessel puncture, and gelatin-tannic acid hydrogel coated needles may help to prevent complications associated with arterial puncture. |
| first_indexed | 2024-04-24T08:41:33Z |
| format | Article |
| id | doaj.art-d0c70f9b62c042359a470b17331d614b |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:41:33Z |
| publishDate | 2022-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-d0c70f9b62c042359a470b17331d614b2024-04-16T15:41:55ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-06-0112133142Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial punctureXingjie Yin0Jingli Ren1Wei Lan2Yu Chen3Mengping Ouyang4Hua Su5Lianbin Zhang6Jintao Zhu7Chun Zhang8Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, 430022, ChinaKey Lab of Material Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, ChinaState Key Laboratory of Coal Combustion and School of Energy and Power Engineering, Huazhong University of Science and Technology, Wuhan, 430074, ChinaKey Lab of Material Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, ChinaKey Lab of Material Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, ChinaDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, 430022, ChinaKey Lab of Material Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, ChinaKey Lab of Material Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, ChinaDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, 430022, China; Corresponding author.Although common in clinical practice, bleeding after tissue puncture may cause serious outcomes, especially in arterial puncture. Herein, gelatin-tannic acid composite hydrogels with varying compositions are prepared, and their adhesive properties are further optimized in microfluidic channel-based simulated vessels for haemostasis in arterial puncture. It is revealed that the composite hydrogels on the syringe needles used for arterial puncture should possess underwater adhesion higher than 4.9 kPa and mechanical strength higher than 86.0 kPa. The needles coated with the gelatin-tannic acid composite hydrogel completely prevent blood loss after both vein and arterial puncture in different animal models. This study holds great significance for the preparation of haemostatic needles for vessel puncture, and gelatin-tannic acid hydrogel coated needles may help to prevent complications associated with arterial puncture.http://www.sciencedirect.com/science/article/pii/S2452199X21004680Gelatin hydrogelUnderwater adhesiveMicrofluidicsHaemostatic coatingVessel puncture |
| spellingShingle | Xingjie Yin Jingli Ren Wei Lan Yu Chen Mengping Ouyang Hua Su Lianbin Zhang Jintao Zhu Chun Zhang Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture Bioactive Materials Gelatin hydrogel Underwater adhesive Microfluidics Haemostatic coating Vessel puncture |
| title | Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture |
| title_full | Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture |
| title_fullStr | Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture |
| title_full_unstemmed | Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture |
| title_short | Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture |
| title_sort | microfluidics assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture |
| topic | Gelatin hydrogel Underwater adhesive Microfluidics Haemostatic coating Vessel puncture |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21004680 |
| work_keys_str_mv | AT xingjieyin microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture AT jingliren microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture AT weilan microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture AT yuchen microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture AT mengpingouyang microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture AT huasu microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture AT lianbinzhang microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture AT jintaozhu microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture AT chunzhang microfluidicsassistedoptimizationofhighlyadhesivehaemostatichydrogelcoatingforarterialpuncture |